A0A318D377 · A0A318D377_9GAMM

  • Protein
    UDP-2,3-diacylglucosamine hydrolase
  • Gene
    lpxH
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 Mn2+ ions per subunit in a binuclear metal center.

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 4/6.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site7Mn2+ 1 (UniProtKB | ChEBI)
Binding site9Mn2+ 1 (UniProtKB | ChEBI)
Binding site40Mn2+ 2 (UniProtKB | ChEBI)
Binding site40Mn2+ 1 (UniProtKB | ChEBI)
Binding site78Mn2+ 2 (UniProtKB | ChEBI)
Binding site78-79substrate
Binding site113Mn2+ 2 (UniProtKB | ChEBI)
Binding site121substrate
Binding site159substrate
Binding site163substrate
Binding site166substrate
Binding site194Mn2+ 2 (UniProtKB | ChEBI)
Binding site194substrate
Binding site196Mn2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentextrinsic component of plasma membrane
Molecular Functionmanganese ion binding
Molecular FunctionUDP-2,3-diacylglucosamine hydrolase activity
Biological Processlipid A biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UDP-2,3-diacylglucosamine hydrolase
  • EC number
  • Alternative names
    • UDP-2,3-diacylglucosamine diphosphatase

Gene names

    • Name
      lpxH
    • ORF names
      DL796_00950

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • ATCC BAA-2076
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Kangiellales > Kangiellaceae > Kangiella

Accessions

  • Primary accession
    A0A318D377

Proteomes

Subcellular Location

Cell inner membrane
; Peripheral membrane protein

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-198Calcineurin-like phosphoesterase

Sequence similarities

Belongs to the LpxH family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    239
  • Mass (Da)
    27,444
  • Last updated
    2018-10-10 v1
  • Checksum
    F1ED970D4DA89B9C
MIHIISDLHLCEERPDLTALFEHFMDEIAPQSEALYVLGDLYESWIGDDDDSAFVESTIQKFKAYSDSGKKLYFQHGNRDFLLGDSFAQKTGGELLDEVHSIQLGDKKAIMMHGDSLCWDDKEYMQFREIVRSEQWQQQLLSQPLEVRRGIAADLRAKSRQAQENKASAITDVHPQAVEEVLQKSDAKILIHGHTHRPDFHDIEVDGKHCQRIVLSDWGEKGHYLAVLDDSICEHYFTT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QICH01000001
EMBL· GenBank· DDBJ
PXF63746.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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