A0A317C3I8 · A0A317C3I8_9GAMM
- ProteinExodeoxyribonuclease I
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids475 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
function
Degrades single-stranded DNA (ssDNA) in a highly processive manner. Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage of DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease or AP lyase.
Catalytic activity
Cofactor
Note: Binds 2 Mg2+ ions per monomer.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | DNA binding | |
Molecular Function | metal ion binding | |
Molecular Function | single-stranded DNA 3'-5' DNA exonuclease activity | |
Biological Process | DNA repair |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameExodeoxyribonuclease I
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Thiotrichales > Thiotrichaceae > Leucothrix
Accessions
- Primary accessionA0A317C3I8
Proteomes
Interaction
Subunit
Monomer. Interacts with ssb (via C-terminus); this interaction stimulates the exonuclease activity by recruiting the enzyme to its substrate.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 197-351 | ExoI SH3-like | ||||
Sequence: PRLYEFYFALRQKNKAAELLNLEKQKTVLHISGMIPASMGCVSPIVPLMQHPVNSNEFICFDLRQHPQQLLNASVEEIEYSLYTPNAERDDDSPRIALKGVHINKCPALAPTNTLTPELAEKWQINWDEIEQHKQLLLADSGLKAKLKALYSAPR | ||||||
Domain | 354-475 | ExoI C-terminal | ||||
Sequence: GPVDADSALYNGFINNEDRKLCNFVINQSAERLAHENIAFSDPRLQTLLFRYRARNWPETLDQQEQWKWQEFCRARLIDGEFGCEFTANDFQDVMQDIAQRDLSDGQKVALQGLLDWVQGLQ |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length475
- Mass (Da)54,407
- Last updated2018-10-10 v1
- ChecksumF6636956A2141E66
Keywords
- Technical term