A0A2V4VCH2 · A0A2V4VCH2_PAEBA

Function

function

DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site188[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site195[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site198[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site204[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular FunctionDNA binding
Molecular FunctionDNA N-glycosylase activity
Molecular Functionendonuclease activity
Molecular Functionmetal ion binding
Biological Processbase-excision repair, AP site formation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Endonuclease III
  • EC number
  • Alternative names
    • DNA-(apurinic or apyrimidinic site) lyase

Gene names

    • Name
      nth
    • ORF names
      DFQ00_10263

Organism names

  • Taxonomic identifier
  • Strain
    • CECT 7022
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Paenibacillaceae > Paenibacillus

Accessions

  • Primary accession
    A0A2V4VCH2

Proteomes

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain38-186HhH-GPD
Region212-238Disordered

Sequence similarities

Belongs to the Nth/MutY family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    238
  • Mass (Da)
    27,233
  • Last updated
    2018-09-12 v1
  • Checksum
    89D6D3FF63657D88
MNAATVRHILETMEAMFPDAHCELNHSNAFELTVAVLLSAQCTDETVNKVTADLFQKYKSPADYLSVPLEELEQDIRRIGLYRNKAKHIQNMCRILIEQYGGDVPQEHDQLVTLPGVGRKTANVVVSNAFGVPAIAVDTHVERVSKRLGLAGWDDSVLEVEKKLMKRVPRDEWTITHHRFIFFGRYHCKAQSPQCHVCPLLDICREGKKRMKTSQIRKDKERVTPRKRKLNSTAEKDE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QJSW01000002
EMBL· GenBank· DDBJ
PYE51272.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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