A0A2T5GF79 · A0A2T5GF79_HYDSH

Function

function

Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site183-184ATP (UniProtKB | ChEBI)
Binding site208-209ATP (UniProtKB | ChEBI)
Binding site265ATP (UniProtKB | ChEBI)
Binding site287ATP (UniProtKB | ChEBI)
Binding site296ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular FunctionCCA tRNA nucleotidyltransferase activity
Molecular FunctiontRNA binding
Molecular FunctiontRNA-uracil-4 sulfurtransferase activity
Biological Processthiamine biosynthetic process
Biological Processthiamine diphosphate biosynthetic process
Biological Processthiazole biosynthetic process
Biological ProcesstRNA 4-thiouridine biosynthesis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable tRNA sulfurtransferase
  • EC number
  • Alternative names
    • Sulfur carrier protein ThiS sulfurtransferase
    • Thiamine biosynthesis protein ThiI
    • tRNA 4-thiouridine synthase

Gene names

    • Name
      thiI
    • ORF names
      HSCHL_1784

Organism names

Accessions

  • Primary accession
    A0A2T5GF79

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain62-165THUMP

Sequence similarities

Belongs to the ThiI family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    406
  • Mass (Da)
    44,918
  • Last updated
    2018-07-18 v1
  • Checksum
    2F6D3F624DAA7000
MIDVYTTVLIRFGELALKGKNRADFEARLIQDIKRRLKAFPELAFWRTHGRLYIELGGTPYEAVAEPLQRIFGLISFSPAIRVPLELEAIQAAALRLVEAARPKTFKVSARRTARAFPVPTPELMKRVGAYVLKRVPGLKVDVHAPEQEVMVEVRQEGAFVYDRVVPGAGGFPVGTSGKVVLLLSGGIDSPVAGWYIMRKGVEVEAVYYHSPPYTSERAKLKVAELARLLSLWSGRVRLRVVPFTEIQEALKASVPEPLLTTFMRRYMMRIAERIADEVGALALATGESLGQVASQTLENLHVIAAATRLPVLRPLIGLDKTEIIALARKIGTYETSILPYEDCCTVFTPAHPQTKPKLAKVEAIEARAGLDREGMIGRALQGTEVLELSPETPPARFEAELELYL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PEBV01000001
EMBL· GenBank· DDBJ
PTQ54841.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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