A0A2S0JHZ3 · A0A2S0JHZ3_9BACI

Function

function

Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.

Features

Showing features for binding site, active site.

142550100150200250300350400
TypeIDPosition(s)Description
Binding site59Zn2+ 1 (UniProtKB | ChEBI)
Binding site61Zn2+ 1 (UniProtKB | ChEBI)
Binding site61-63substrate
Binding site93substrate
Binding site151Zn2+ 2 (UniProtKB | ChEBI)
Binding site151Zn2+ 1 (UniProtKB | ChEBI)
Binding site178Zn2+ 2 (UniProtKB | ChEBI)
Binding site231Zn2+ 2 (UniProtKB | ChEBI)
Binding site277substrate
Active site304
Binding site304Zn2+ 1 (UniProtKB | ChEBI)
Binding site308substrate
Binding site322-323substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionallantoinase activity
Molecular Functiondihydroorotase activity
Molecular Functionzinc ion binding
Biological Process'de novo' UMP biosynthetic process
Biological Processpurine nucleobase catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotase
  • EC number
  • Short names
    DHOase

Gene names

    • Name
      pyrC
    • ORF names
      C3943_05680

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • B2A1
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Lysinibacillus

Accessions

  • Primary accession
    A0A2S0JHZ3

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain50-420Amidohydrolase-related

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    425
  • Mass (Da)
    45,996
  • Last updated
    2018-07-18 v1
  • Checksum
    A1208EF11D07496A
MTKILQNVQMLNEQGELHTVNIAMAEGKITAIGQDVTVEDAEIIEGNGFVVAPGFVDVHTHLREPGFEHKETIATGSASAAKGGFTTICAMPNTKPVPDSVENMKLINGLIKESAVIRVLPYGSLTKDISGEVRTNIEELKAQGAVAFSDDGVGIQLASTMYEQMKDAAQHDMVVVAHCEDNSLIYDGVMHEGKRNKELGLPGIPSICESVQIARDVLLAEAAGARYHVCHVSTKESVRAVRDAKAAGIRVTAEVCPHHLLLEEMDIPSDDANWKMNPPLRGADDKDSLHAALLDGTIDCIATDHAPHTVEEKCCGMVGAPFGIVGFETAFPLLYTQFVETGKWTLKQLIDWMTVKAAQIFDLPYGTLEVGSSADMILIDLNKEQTIDAEGFVSKGRNTPFNGWAAKGWPVLTIFEGNIVYQEAE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP027224
EMBL· GenBank· DDBJ
AVK83086.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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