A0A2R6PI27 · LDOX_ACTCC

Function

function

Involved in anthocyanin biosynthesis by catalyzing the oxidation of leucoanthocyanidins into anthocyanidins (PubMed:30912865).
Required for the accumulation of anthocyanin in red-fleshed kiwifruit varieties (PubMed:30912865).

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
L-ascorbate (UniProtKB | Rhea| CHEBI:38290 )

Note: Binds 1 ascorbate molecule per subunit.
Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Note: Binds 1 Fe2+ ion per subunit.

Pathway

Pigment biosynthesis; anthocyanin biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site145substrate
Binding site216substrate
Binding site218-2202-oxoglutarate (UniProtKB | ChEBI)
Binding site235Fe cation (UniProtKB | ChEBI)
Binding site236substrate
Binding site237Fe cation (UniProtKB | ChEBI)
Binding site291Fe cation (UniProtKB | ChEBI)
Binding site3012-oxoglutarate (UniProtKB | ChEBI)
Binding site301-3032-oxoglutarate (UniProtKB | ChEBI)
Binding site309substrate
Binding site344substrate

GO annotations

AspectTerm
Molecular FunctionL-ascorbic acid binding
Molecular Functionleucocyanidin oxygenase activity
Molecular Functionmetal ion binding
Molecular Functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated
Biological Processanthocyanin-containing compound biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Anthocyanin synthase
  • EC number
  • Short names
    AcANS
  • Alternative names
    • Leucoanthocyanidin dioxygenase
      (AcLDOX
      ; Leucocyanidin oxygenase
      )

Gene names

    • Name
      LDOX
    • Synonyms
      ANS
      , ANS1
      , ANS4
    • ORF names
      CEY00_Acc28876

Organism names

Accessions

  • Primary accession
    A0A2R6PI27
  • Secondary accessions
    • T2DJM4

Proteomes

Genome annotation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004480771-355Anthocyanin synthase

Expression

Tissue specificity

Expressed in stems and leaves (PubMed:25143057).
Expressed at low levels in ovaries (PubMed:21175894, PubMed:25143057).

Developmental stage

Expressed in the inner and outer pericarps of developing fruit from 20 to 49 days after flowering (DAF), and expression decreases as the fruit ripens.

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain211-310Fe2OG dioxygenase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    355
  • Mass (Da)
    39,959
  • Last updated
    2018-06-20 v1
  • Checksum
    3153D1F58830B37B
MVATVVGTRVESLASSGIEAIPKEYVRPQEELTSIGNIFEEEKKENGPQVPTIDLEDLVSEDEEKRVRCHEELKRAATEWGVMQVVNHGIPIELMERVRAAGAEFFNQSVEEKEKYANDHASGNIQGYGSKLANNASGQLEWEDYFFHLVYPEDKRDMSIWPKTPSDYIPATSAYAEHLRGLATKILSALSLGLGLEEGRLEKEVGGMEELLLQMKINYYPKCPQPELALGVEAHTDVSALTFILHNMVPGLQLFYEGKWVTAKCVPDSLVMHIGDTIEILSNGKYKSILHRGLVNKEKVRISWAVFCEPPKEKIILKPLPETVSEAEPPLYPPRTFAQHIHHKLFRKTQELGAK

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict42in Ref. 1; AGV53047
Sequence conflict60in Ref. 1; AGV53047
Sequence conflict201in Ref. 1; AGV53047

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KF157392
EMBL· GenBank· DDBJ
AGV53047.1
EMBL· GenBank· DDBJ
mRNA
NKQK01000025
EMBL· GenBank· DDBJ
PSR91531.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp