A0A2M8PGN0 · A0A2M8PGN0_9CHLR
- Protein3-isopropylmalate dehydratase large subunit
- GeneleuC
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids472 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Catalytic activity
- (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate
Cofactor
Note: Binds 1 [4Fe-4S] cluster per subunit.
Pathway
Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3-isopropylmalate dehydratase activity | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | metal ion binding | |
Biological Process | L-leucine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-isopropylmalate dehydratase large subunit
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Chloroflexota > Candidatus Thermofonsia > Candidatus Thermofonsia Clade 1
Accessions
- Primary accessionA0A2M8PGN0
Proteomes
Interaction
Subunit
Heterodimer of LeuC and LeuD.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 9-460 | Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha | ||||
Sequence: EKVWERHLVAPQTDESPAVLYIDLHLVHEVTSPQAFTMLRERGLKVRRPDCTLGTMDHSTPTTPLDIPIMDAQAAAQIEQMKRNCAEFGVPLYALGSAYQGIVHVIGPELGLTQPGMTIVCGDSHTSTHGAFGALAFGIGTSEVGHVLATQCLLQNKPKTMAVRVEGSLKLGVSAKDVILALIAKIGVGGGTGYVFEYCGSAIRALSMEERMTICNMSIEGGARAGMVAPDETTFAYLEGRPFAPKGEAWECAVADWRTLPTDEGAVFDAEVYIDADSLEPMITYGTNPGMGMPITGRIPDPDSIGDPSQRETLIKALKYMDLQPNAPLLGHKIDVVFLGSCTNSRLSDLRAAAALLKGHKIAPNVRMLVVPGSQQVKRQAEAEGLHEIFKAAGAEWREAGCSMCIAMNGDQLQPGEYAVSTSNRNFEGRQGKGGRTFLASPLTAVASAING |
Sequence similarities
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length472
- Mass (Da)50,627
- Last updated2018-04-25 v1
- ChecksumA2F65CC244DC527C