A0A2M8PGN0 · A0A2M8PGN0_9CHLR

Function

function

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site350[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site410[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site413[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function3-isopropylmalate dehydratase activity
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionmetal ion binding
Biological ProcessL-leucine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-isopropylmalate dehydratase large subunit
  • EC number
  • Alternative names
    • Alpha-IPM isomerase
      (IPMI
      )
    • Isopropylmalate isomerase

Gene names

    • Name
      leuC
    • ORF names
      CUN49_04075

Organism names

Accessions

  • Primary accession
    A0A2M8PGN0

Proteomes

Interaction

Subunit

Heterodimer of LeuC and LeuD.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-460Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha

Sequence similarities

Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    472
  • Mass (Da)
    50,627
  • Last updated
    2018-04-25 v1
  • Checksum
    A2F65CC244DC527C
MSQPRTLFEKVWERHLVAPQTDESPAVLYIDLHLVHEVTSPQAFTMLRERGLKVRRPDCTLGTMDHSTPTTPLDIPIMDAQAAAQIEQMKRNCAEFGVPLYALGSAYQGIVHVIGPELGLTQPGMTIVCGDSHTSTHGAFGALAFGIGTSEVGHVLATQCLLQNKPKTMAVRVEGSLKLGVSAKDVILALIAKIGVGGGTGYVFEYCGSAIRALSMEERMTICNMSIEGGARAGMVAPDETTFAYLEGRPFAPKGEAWECAVADWRTLPTDEGAVFDAEVYIDADSLEPMITYGTNPGMGMPITGRIPDPDSIGDPSQRETLIKALKYMDLQPNAPLLGHKIDVVFLGSCTNSRLSDLRAAAALLKGHKIAPNVRMLVVPGSQQVKRQAEAEGLHEIFKAAGAEWREAGCSMCIAMNGDQLQPGEYAVSTSNRNFEGRQGKGGRTFLASPLTAVASAINGCVTDPREMLERV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PGTM01000036
EMBL· GenBank· DDBJ
PJF36706.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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