A0A2M4A7U0 · A0A2M4A7U0_9DIPT

  • Protein
    6-phosphogluconate dehydrogenase, decarboxylating
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.

Catalytic activity

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.

Features

Showing features for binding site, active site.

148250100150200250300350400450
TypeIDPosition(s)Description
Binding site12-17NADP+ (UniProtKB | ChEBI)
Binding site35-37NADP+ (UniProtKB | ChEBI)
Binding site77-79NADP+ (UniProtKB | ChEBI)
Binding site105NADP+ (UniProtKB | ChEBI)
Binding site105substrate; ligand shared between dimeric partners; in other chain
Binding site131-133substrate; ligand shared between dimeric partners; in other chain
Active site185Proton acceptor
Binding site188-189substrate; ligand shared between dimeric partners; in other chain
Active site192Proton donor
Binding site193substrate; ligand shared between dimeric partners; in other chain
Binding site260substrate; ligand shared between dimeric partners; in other chain
Binding site287substrate; ligand shared between dimeric partners; in other chain
Binding site446substrate; ligand shared between dimeric partners
Binding site452substrate; ligand shared between dimeric partners

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular FunctionNADP binding
Molecular Functionphosphogluconate dehydrogenase (decarboxylating) activity
Biological ProcessD-gluconate metabolic process
Biological Processpentose-phosphate shunt

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    6-phosphogluconate dehydrogenase, decarboxylating
  • EC number

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Anophelinae > Anopheles

Accessions

  • Primary accession
    A0A2M4A7U0

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain181-4696-phosphogluconate dehydrogenase C-terminal

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    482
  • Mass (Da)
    53,126
  • Last updated
    2018-04-25 v1
  • Checksum
    834F7D654F7A9F75
MSSPKADIALIGLAVMGQNLILNMDSKGFVVCAYNRTVDKVTHFLENEAKGTNIIGATSLQDMVNKLKTPRKIMLLVKAGSAVDDFIQQLLPLIERGDVIIDGGNSEHQDSARRYEELKAKGILYVGSGVSGGEEGARYGPSLMPGGHPDAWPLIKDIFQAICAKSNGDPCCEWVGEGGAGHFVKMVHNGIEYGDMQLICEAYHLMLALGMTQKEMAQEFDEWNKGVLDSFLIEITRDILNYRDEEGYLLERIRDTAGQKGTGKWTAIAALHHGVPVTLIGEAVFSRCLSALKDERARASKQLAGPSTKASVSDRKQFLTHIRNALYCAKIVSYAQGFMLLREAANEYKWNLNYGGIALMWRGGCIIRSVFLGNIRDAFVRNPQLSNLLLDDFFRKAMMDNQQSWREVVSQAVLWGVPVPALSAALAFFDGYRSERLPANLLQAQRDYFGAHTYELLGKEGAFVHTNWTGKGGNVSASTYLA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GGFK01003533
EMBL· GenBank· DDBJ
MBW36854.1
EMBL· GenBank· DDBJ
Transcribed RNA

Similar Proteins

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