A0A2L1K1W2 · A0A2L1K1W2_9CHIR
- ProteinCytochrome b
- GeneCYTB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids366 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 2 heme groups non-covalently.
Note: Binds 2 heme groups non-covalently.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 75 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 89 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 174 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 188 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 193 | a ubiquinone (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex III | |
Molecular Function | metal ion binding | |
Molecular Function | ubiquinol-cytochrome-c reductase activity | |
Biological Process | mitochondrial electron transport, ubiquinol to cytochrome c |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCytochrome b
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yangochiroptera > Vespertilionidae > Glauconycteris
Accessions
- Primary accessionA0A2L1K1W2
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 22-48 | Helical | ||||
Sequence: WWNFGSLLGICLALQILTGLFLAMHYT | ||||||
Transmembrane | 69-90 | Helical | ||||
Sequence: WVLRYLHANGASMFFICLYLHV | ||||||
Transmembrane | 105-125 | Helical | ||||
Sequence: WNMGVILLFAVMATAFMGYVL | ||||||
Transmembrane | 137-158 | Helical | ||||
Sequence: VITNLLSAIPYIGTTLVEWIWG | ||||||
Transmembrane | 170-192 | Helical | ||||
Sequence: FFAFHFLLPFIISAMVMIHLLFL | ||||||
Transmembrane | 221-238 | Helical | ||||
Sequence: ILGVFMMITTLLALVLFS | ||||||
Transmembrane | 280-299 | Helical | ||||
Sequence: LGGVLALVLSIMILIIIPLL | ||||||
Transmembrane | 311-332 | Helical | ||||
Sequence: PISQCLFWLLTADLLTLTWIGG | ||||||
Transmembrane | 338-360 | Helical | ||||
Sequence: PYIIIGQLASVLYFLTILVLMPL |
Keywords
- Cellular component
Interaction
Subunit
The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-201 | Cytochrome b/b6 N-terminal region profile | ||||
Sequence: PLMKIINESFIDLPAPSNISAWWNFGSLLGICLALQILTGLFLAMHYTSDTATAFNSVTHICRDVNYGWVLRYLHANGASMFFICLYLHVGRGLYYGSYLFKETWNMGVILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFLLPFIISAMVMIHLLFLHETGSNNPT | ||||||
Domain | 202-366 | Cytochrome b/b6 C-terminal region profile | ||||
Sequence: GIPSNTDMIPFHPYYTIKDILGVFMMITTLLALVLFSPDMLGDPDNYIPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSIMILIIIPLLHTSKQRSMSFRPISQCLFWLLTADLLTLTWIGGQPVEHPYIIIGQLASVLYFLTILVLMPLTSLLEN |
Sequence similarities
Belongs to the cytochrome b family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length366
- Mass (Da)41,194
- Last updated2018-04-25 v1
- Checksum7178D39D7A19DDB3
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: P | ||||||
Non-terminal residue | 366 | |||||
Sequence: N |