A0A2L1K1W2 · A0A2L1K1W2_9CHIR

Function

function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.

Cofactor

Protein has several cofactor binding sites:
heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 2 heme groups non-covalently.
heme (UniProtKB | Rhea| CHEBI:30413 )

Note: Binds 2 heme groups non-covalently.

Features

Showing features for binding site.

136650100150200250300350
TypeIDPosition(s)Description
Binding site75Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site89Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site174Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site188Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site193a ubiquinone (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex III
Molecular Functionmetal ion binding
Molecular Functionubiquinol-cytochrome-c reductase activity
Biological Processmitochondrial electron transport, ubiquinol to cytochrome c

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome b

Gene names

    • Name
      CYTB

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strain
    • R13x20
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yangochiroptera > Vespertilionidae > Glauconycteris

Accessions

  • Primary accession
    A0A2L1K1W2

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane22-48Helical
Transmembrane69-90Helical
Transmembrane105-125Helical
Transmembrane137-158Helical
Transmembrane170-192Helical
Transmembrane221-238Helical
Transmembrane280-299Helical
Transmembrane311-332Helical
Transmembrane338-360Helical

Keywords

Interaction

Subunit

The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-201Cytochrome b/b6 N-terminal region profile
Domain202-366Cytochrome b/b6 C-terminal region profile

Sequence similarities

Belongs to the cytochrome b family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    366
  • Mass (Da)
    41,194
  • Last updated
    2018-04-25 v1
  • Checksum
    7178D39D7A19DDB3
PLMKIINESFIDLPAPSNISAWWNFGSLLGICLALQILTGLFLAMHYTSDTATAFNSVTHICRDVNYGWVLRYLHANGASMFFICLYLHVGRGLYYGSYLFKETWNMGVILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFLLPFIISAMVMIHLLFLHETGSNNPTGIPSNTDMIPFHPYYTIKDILGVFMMITTLLALVLFSPDMLGDPDNYIPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSIMILIIIPLLHTSKQRSMSFRPISQCLFWLLTADLLTLTWIGGQPVEHPYIIIGQLASVLYFLTILVLMPLTSLLEN

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue366

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MF038515
EMBL· GenBank· DDBJ
AVE14691.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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