A0A2J7QDG3 · A0A2J7QDG3_9NEOP

  • Protein
    Prostaglandin reductase 1
  • Gene
    PTGR1_5
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • (5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP+ = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H+
    This reaction proceeds in the forward direction.
  • 13,14-dihydro-15-oxo-PGF2alpha + NADP+ = 15-oxoprostaglandin F2alpha + NADPH + H+
    This reaction proceeds in the backward direction.
  • 13,14-dihydro-15-oxo-prostaglandin E1 + NADP+ = 15-oxoprostaglandin E1 + NADPH + H+
    This reaction proceeds in the backward direction.
  • 13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP+ = 15-oxoprostaglandin F1alpha + NADPH + H+
    This reaction proceeds in the backward direction.
  • 20-hydroxy-leukotriene B4 + NADP+ = 12-oxo-20-hydroxy-leukotriene B4 + NADPH + H+
    This reaction proceeds in the forward direction.
  • 4-hydroxynonanal + NADP+ = (E)-4-hydroxynon-2-enal + NADPH + H+
    This reaction proceeds in the backward direction.
  • 6-trans-leukotriene B4 + NADP+ = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H+
    This reaction proceeds in the forward direction.
  • nonan-2-one + NADP+ = (3E)-nonen-2-one + NADPH + H+
    This reaction proceeds in the backward direction.
  • octanal + NADP+ = (2E)-octenal + NADPH + H+
    This reaction proceeds in the backward direction.
  • pentan-2-one + NADP+ = (E)-pent-3-en-2-one + NADPH + H+
    This reaction proceeds in the backward direction.
  • an n-alkanal + NADP+ = an alk-2-enal + NADPH + H+
    This reaction proceeds in the backward direction.
    EC:1.3.1.74 (UniProtKB | ENZYME | Rhea)
  • decanal + NADP+ = (2E)-decenal + NADPH + H+
    This reaction proceeds in the backward direction.
  • dodecanal + NADP+ = (2E)-dodecenal + NADPH + H+
    This reaction proceeds in the backward direction.
  • hexanal + NADP+ = (E)-hex-2-enal + NADPH + H+
    This reaction proceeds in the backward direction.
  • leukotriene B4 + NADP+ = 12-oxo-leukotriene B4 + NADPH + H+
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function15-oxoprostaglandin 13-oxidase [NAD(P)+] activity
Molecular Function2-alkenal reductase [NAD(P)+] activity
Biological Processprostaglandin metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Prostaglandin reductase 1
  • EC number
  • Alternative names
    • 15-oxoprostaglandin 13-reductase
    • Dithiolethione-inducible gene 1 protein
    • Leukotriene B4 12-hydroxydehydrogenase
    • NAD(P)H-dependent alkenal/one oxidoreductase

Gene names

    • Name
      PTGR1_5
    • ORF names
      B7P43_G10722

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Polyneoptera > Dictyoptera > Blattodea > Blattoidea > Termitoidae > Kalotermitidae > Cryptotermitinae > Cryptotermes

Accessions

  • Primary accession
    A0A2J7QDG3

Proteomes

Subcellular Location

PTM/Processing

Keywords

Interaction

Subunit

Monomer or homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain18-335Enoyl reductase (ER)

Sequence similarities

Belongs to the NADP-dependent oxidoreductase L4BD family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    337
  • Mass (Da)
    37,248
  • Last updated
    2018-03-28 v1
  • Checksum
    102B8F9C333CA140
MVKTKKFILVKHFVGEPKENDFQLVEEDLPALRDREILCEAVWLSVDPYMRPFSNNFPTGVTMTGTQVAKVTESCHPEYKVGMHVVGDFGWQTRAVVNADDPGASLWLEKPYIIPDFSGLPLSLALGVLGMPGNTAYFGFLEICDPKPGDVVVVSGAAGAVGSHVGQIAQLKGCKVIGFTGSDEKVKWLVDELRFDAAFNYKTTDVVEALKQSTPEGVDCYFDNVGGALSSAVISQMRFRGRISVCGSISSYNADISKLPQAPDIQRTVLRKELKMEGFSVKYWNDRWDEGIKQNLQWIKEGKLVYRETVTEGFENMTKAFIGMLRGENIGKAVVKV

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2J7QDH2A0A2J7QDH2_9NEOPPTGR1_5421
A0A2J7QDF6A0A2J7QDF6_9NEOPPTGR1_5275
A0A2J7QDF8A0A2J7QDF8_9NEOPPTGR1_5402
A0A2J7QDG7A0A2J7QDG7_9NEOPPTGR1_5288

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NEVH01015823
EMBL· GenBank· DDBJ
PNF26620.1
EMBL· GenBank· DDBJ
Genomic DNA
NEVH01015823
EMBL· GenBank· DDBJ
PNF26621.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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