A0A2I0PJ79 · A0A2I0PJ79_9EURY
- ProteinDigeranylgeranylglyceryl phosphate synthase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids275 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
Catalytic activity
- (2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate
Cofactor
Pathway
Membrane lipid metabolism; glycerophospholipid metabolism.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | geranylgeranylglycerol-phosphate geranylgeranyltransferase activity | |
Molecular Function | magnesium ion binding | |
Biological Process | glycerophospholipid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDigeranylgeranylglyceryl phosphate synthase
- EC number
- Short namesDGGGP synthase ; DGGGPS
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Methanomada group > Methanobacteria > Methanobacteriales
Accessions
- Primary accessionA0A2I0PJ79
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 7-26 | Helical | ||||
Sequence: ILRPFNAMMAVITIVLMAVI | ||||||
Transmembrane | 32-55 | Helical | ||||
Sequence: FNVFLAGIVVFISTGAGNAINDYF | ||||||
Transmembrane | 189-207 | Helical | ||||
Sequence: YGKKVSSIIASFFMILASL | ||||||
Transmembrane | 213-234 | Helical | ||||
Sequence: YFLGIFSILYLIVLAVGIVIFL | ||||||
Transmembrane | 255-274 | Helical | ||||
Sequence: QIKIGMAIVFLAFLIGSPIF |
Keywords
- Cellular component
Structure
Family & Domains
Sequence similarities
Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length275
- Mass (Da)30,088
- Last updated2018-02-28 v1
- Checksum555F9EB3FDA83BF9