A0A2H4PX57 · A0A2H4PX57_9NEOB

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      CO1
    • Synonyms
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • CIB20110629001
    • CIB2011081601
    • CIB2011081602
    • CIB2011081603
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Neobatrachia > Ranoidea > Ranidae > Nidirana

Accessions

  • Primary accession
    A0A2H4PX57

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane22-52Helical
Transmembrane73-95Helical
Transmembrane115-140Helical
Transmembrane152-179Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-187Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    187
  • Mass (Da)
    20,012
  • Last updated
    2018-02-28 v1
  • Checksum
    CAF5A581EA7CD5B6
ALSLLIRAELSQPGALLGDDQIYNVIVTAHAFVMIFFMVMPILIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFFLLLASSTVEAGVGTGWTVYPPLAGNLAHAGPSVDLAIFSLHLAGVSSILGAINFITTIINMKPPSTTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTT

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue187

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MF807861
EMBL· GenBank· DDBJ
ATW75894.1
EMBL· GenBank· DDBJ
Genomic DNA
MF807862
EMBL· GenBank· DDBJ
ATW75895.1
EMBL· GenBank· DDBJ
Genomic DNA
MF807863
EMBL· GenBank· DDBJ
ATW75896.1
EMBL· GenBank· DDBJ
Genomic DNA
MF807864
EMBL· GenBank· DDBJ
ATW75897.1
EMBL· GenBank· DDBJ
Genomic DNA
MF807865
EMBL· GenBank· DDBJ
ATW75898.1
EMBL· GenBank· DDBJ
Genomic DNA
MK293837
EMBL· GenBank· DDBJ
QBB86101.1
EMBL· GenBank· DDBJ
Genomic DNA
MK293838
EMBL· GenBank· DDBJ
QBB86102.1
EMBL· GenBank· DDBJ
Genomic DNA
MK293839
EMBL· GenBank· DDBJ
QBB86103.1
EMBL· GenBank· DDBJ
Genomic DNA
MK293840
EMBL· GenBank· DDBJ
QBB86104.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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