A0A2E0LIU3 · A0A2E0LIU3_9GAMM
- ProteinMalate dehydrogenase
- Genemdh
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids326 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the reversible oxidation of malate to oxaloacetate.
Catalytic activity
- (S)-malate + NAD+ = H+ + NADH + oxaloacetate
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 11-17 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GAAGQIS | ||||||
Binding site | 92 | substrate | ||||
Sequence: R | ||||||
Binding site | 98 | substrate | ||||
Sequence: R | ||||||
Binding site | 105 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 112 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 129-131 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: VGN | ||||||
Binding site | 131 | substrate | ||||
Sequence: N | ||||||
Binding site | 162 | substrate | ||||
Sequence: R | ||||||
Active site | 187 | Proton acceptor | ||||
Sequence: H |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | L-malate dehydrogenase activity | |
Biological Process | malate metabolic process | |
Biological Process | NADH metabolic process | |
Biological Process | oxaloacetate metabolic process | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMalate dehydrogenase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Cellvibrionales > Porticoccaceae
Accessions
- Primary accessionA0A2E0LIU3
Proteomes
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 5-149 | Lactate/malate dehydrogenase N-terminal | ||||
Sequence: VRVAVTGAAGQISYSLLFRIAAGEMLGPDQPVILQLLEITPALPALAGVAMELEDCAFPLLAGIVQTDDAKIAFRDADYALLVGARPRGPGMERKDLLEANANIFSVQGKAINDCASREIRVLVVGNPANTNALIAQRNAPDIDP | ||||||
Domain | 156-320 | Lactate/malate dehydrogenase C-terminal | ||||
Sequence: TRLDHNRALTQVAVQTGTTVNDVRRMTIWGNHSATQYPDLHHTLVKGRPALELVDRTWYENEMIPLVQQRGAAVIKARGASSAASAANAALAHMRSWALGSPADDWVSMGIFSDGSYGIAEGLIYSFPCVCEGGDWRIVQGLEINDFSRQKMTETETELGEERDA |
Sequence similarities
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length326
- Mass (Da)35,312
- Last updated2018-04-25 v1
- ChecksumD0E602C4112A01C7