A0A2D4M9A1 · A0A2D4M9A1_9SAUR
- ProteinNuclear factor NF-kappa-B p105 subunit
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids975 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
function
Constitutes the active form, which associates with RELA/p65 to form the NF-kappa-B p65-p50 complex to form a transcription factor. Together with RELA/p65, binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameNuclear factor NF-kappa-B p105 subunit
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Lepidosauria > Squamata > Bifurcata > Unidentata > Episquamata > Toxicofera > Serpentes > Colubroidea > Elapidae > Elapinae > Micrurus
Accessions
- Primary accessionA0A2D4M9A1
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, repeat, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 45-252 | RHD | ||||
Sequence: TDGPYLQIVEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICSYAGPAKVIVQLVTNGKHVHLHAHSLVGKHCEQGVCTVNAGPKDMVVGFPNLGILHVTKKKVLDTLEMRMIDACKKGYNPGLLVHSDLNYIQVEGGGERQLTEREREIIHQAAHQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLQPVLSDPIYDSKAPN | ||||||
Repeat | 536-568 | ANK | ||||
Sequence: NGDNVLHLAIIHLHMELVKNLLEVIANMNTAAV | ||||||
Repeat | 575-607 | ANK | ||||
Sequence: LYQTPLHLAVITRQAGIVRALLGAGADVNLLDR | ||||||
Repeat | 644-676 | ANK | ||||
Sequence: DGLTVLHLAVIANSMPCLRLLLAVGVDVNIQEQ | ||||||
Repeat | 678-711 | ANK | ||||
Sequence: SGRTALHLAIEQGNISMAGCLLLEGDAFVDSVTY | ||||||
Repeat | 712-744 | ANK | ||||
Sequence: DGTTPLHIAAGRGSTKLAALLKAAGADPHIENF | ||||||
Region | 884-907 | Disordered | ||||
Sequence: ITSSSQSKQEKTKNDVLPLCDLPS |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length975
- Mass (Da)107,029
- Last updated2018-01-31 v1
- ChecksumC9C77D428ACD7219