A0A290DW16 · A0A290DW16_STECO

Function

function

Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity. Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe2+ and Mn2+, cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentlate endosome membrane
Cellular Componentlysosomal membrane
Cellular Componentphagocytic vesicle membrane
Cellular Componentplasma membrane
Molecular Functioncadmium ion transmembrane transporter activity
Molecular Functioniron ion transmembrane transporter activity
Molecular Functionmanganese ion transmembrane transporter activity
Molecular Functionmetal cation:proton antiporter activity
Biological Processintracellular iron ion homeostasis
Biological Processresponse to lipopolysaccharide

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Natural resistance-associated macrophage protein 1
  • Alternative names
    • Solute carrier family 11 member 1

Gene names

    • Name
      SLC11A1

Organism names

Accessions

  • Primary accession
    A0A290DW16

Subcellular Location

Endosome membrane
; Multi-pass membrane protein
Late endosome membrane
; Multi-pass membrane protein
Lysosome membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane29-52Helical
Transmembrane91-117Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the NRAMP family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    131
  • Mass (Da)
    14,392
  • Last updated
    2017-12-20 v1
  • Checksum
    07E27F8A633281D7
HNIYLHSALVKSREIDRTRRADIREANMYFLIEAAIALSVSFFINLFVVAVFGQAFYQQTNQAAFNVCANSSLHDYAKIFPRNNLTVAVDIYQGGVILGCLFGPAALYIWAVGLLAAGQSSTMTGTYAGQF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue131

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KY202418
EMBL· GenBank· DDBJ
ATB24823.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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