A0A250FAT6 · A0A250FAT6_9FLAO

Function

function

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

Catalytic activity

  • ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.
    EC:7.4.2.8 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site.

111211002003004005006007008009001,0001,100
TypeIDPosition(s)Description
Binding site177ATP (UniProtKB | ChEBI)
Binding site195-199ATP (UniProtKB | ChEBI)
Binding site693ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Biological Processintracellular protein transmembrane transport
Biological Processprotein import
Biological Processprotein targeting

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein translocase subunit SecA
  • EC number

Gene names

    • Name
      secA
    • ORF names
      CGC53_07765

Organism names

  • Taxonomic identifier
  • Strain
    • H6253
  • Taxonomic lineage
    Bacteria > Bacteroidota > Flavobacteriia > Flavobacteriales > Flavobacteriaceae > Capnocytophaga

Accessions

  • Primary accession
    A0A250FAT6

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cytoplasm
Note: Distribution is 50-50.

Keywords

Interaction

Subunit

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.

Family & Domains

Features

Showing features for domain, coiled coil.

TypeIDPosition(s)Description
Domain5-771SecA family profile
Coiled coil53-103
Domain179-338Helicase ATP-binding
Domain603-787Helicase C-terminal

Sequence similarities

Belongs to the SecA family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,121
  • Mass (Da)
    127,766
  • Last updated
    2017-12-20 v1
  • Checksum
    7331D4EF9D9A59C9
MSIINSLIKLFVGDKAKNDLKSIQPLVEKIKAYAAELEHISNDELRGKTIAFKEKIKEARATFDTQIADLQAQANATEDIDKKEDLYTEIDKLSAEAYQASEKVLNDILPEAFATMKETARRFATNETISVTATPRDRELSATHDYVTIEGDKAIWKNHWDAAGKDVTWDMVHYDVQLIGGIALHQGKIAEMQTGEGKTLVATLPVYLNALTGNGVHLVTVNDYLARRDSAWMGPLFEFHGLRVDCIDNHQPNSQARRNAYNADITYGTNNEFGFDYLRDNMAHTSEDLVQRAHNYAIVDEVDSVLIDDARTPLIISGPTPKGDRHEFNELKPLVADLVEKQRTYLTKVLADARKLIAEGNTKEGGFQLLRVYRGLPKNKALIKFLSEEGVKQLLQKTENYYMQDNNREMPKVDAELYFVIDEKNNQIELTDKGFADIASYDGDKNFFVLPDIGVEIADIESQNLPIEEEAKLKEKLLQDFTVKSERIHTLNQLLKAYTLFEKDVEYVLIDNKVLIVDEQTGRIMDGRRYSDGLHQAIEAKENVKIEAATQTYATITLQNYFRMYSKLSGMTGTAITEAGEFWEIYKLDVMEIPTNRPIARKDYNDLIYKTKREKYNAVIDKVVSLSEAGRPVLIGTTSVEVSELLSRMLTMRKIKHNVLNAKLHKKEAEIVAEAGQSGVVTIATNMAGRGTDIKLSPEVKAAGGLAIIGTERHDSRRVDRQLRGRSGRQGDPGSSLFYVSLEDNLMRLFGSERIARLMDKLGHKEGDVIEHSIMTKRIETAQKKVEENNFGIRKRLLEYDDVMNAQREVIYKRRRHALEGERLKVDLANMIFDTCEVIVESNKSANNYKNFEFELIKYFSLKTQISEAEFAKATNNELTFRLYREVLDHYQQKTERSAAQAFPVIREVYENPSNTYERIVVPFTDGQKMLNIVTDLKEAYESAGKKLISDFEKNITLAIIDDEWKTHLRQMDELKQSVQLAVHEQKDPLLIYKFEAFQLFKAMIDKVNKDIVSFLFRAELPTQAPAVQEAHAPQRSNEHYQTNKEEVLNSDEMAAQAREVGQQASQRRSLVETIIREQPKVGRNDKVVIQNIRTGERKELKFKQADPLINSGEWILVSNK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP022384
EMBL· GenBank· DDBJ
ATA82242.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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