A0A218P5X7 · A0A218P5X7_9EURY

  • Protein
    S-methyl-5'-thioadenosine phosphorylase
  • Gene
    mtnP
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site10phosphate (UniProtKB | ChEBI)
Binding site50-51phosphate (UniProtKB | ChEBI)
Binding site83-84phosphate (UniProtKB | ChEBI)
Site163Important for substrate specificity
Binding site180substrate
Binding site181phosphate (UniProtKB | ChEBI)
Binding site204-206substrate
Site215Important for substrate specificity

GO annotations

AspectTerm
Molecular FunctionS-methyl-5-thioadenosine phosphorylase activity
Biological ProcessL-methionine salvage from methylthioadenosine
Biological Processpurine ribonucleoside salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    S-methyl-5'-thioadenosine phosphorylase
  • EC number
  • Alternative names
    • 5'-methylthioadenosine phosphorylase
      (MTA phosphorylase
      ; MTAP
      )

Gene names

    • Name
      mtnP
    • ORF names
      A3L08_02055

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • P-4
  • Taxonomic lineage
    Archaea > Euryarchaeota > Thermococci > Thermococcales > Thermococcaceae > Thermococcus

Accessions

  • Primary accession
    A0A218P5X7

Proteomes

Interaction

Subunit

Homohexamer. Dimer of a homotrimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-237Nucleoside phosphorylase

Sequence similarities

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    257
  • Mass (Da)
    29,043
  • Last updated
    2017-09-27 v1
  • Checksum
    83301D59A5215D0D
MVKIGIIGGSGVYGVFEPKETVKVHTPYGRPSAPVEIGEIEGVEVAFIPRHGKNHEFPPHEVPYRANIWALHELGVERVIGVTAVGSLREEYKPGDIVITDQFIDFTKKRDYTFYNGPRVAHVSMADPFCPEMRKIFYETAKELGFPVHEKGTYVCIEGPRFSTRAESFMFRQYAHIIGMTLVPEINLARELGMCYANIATVTDYDVWADKPVDAQEVLKVMAENNYKVQELLKKAIPRIPEERKCGCADVLKSMFV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP015102
EMBL· GenBank· DDBJ
ASJ06196.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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