A0A1Z2TP61 · A0A1Z2TP61_9EURY

  • Protein
    Diphthine synthase
  • Gene
    dphB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

Catalytic activity

Pathway

Protein modification; peptidyl-diphthamide biosynthesis.

Features

Showing features for binding site.

126420406080100120140160180200220240260
TypeIDPosition(s)Description
Binding site10S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site87S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site90S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site115-116S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site166S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site209S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site234S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functiondiphthine synthase activity
Biological Processmethylation
Biological Processprotein histidyl modification to diphthamide

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Diphthine synthase
  • EC number
  • Alternative names
    • Diphthamide biosynthesis methyltransferase

Gene names

    • Name
      dphB
    • ORF names
      CDI07_07985

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 5-4
  • Taxonomic lineage
    Archaea > Euryarchaeota > Thermococci > Thermococcales > Thermococcaceae > Thermococcus

Accessions

  • Primary accession
    A0A1Z2TP61

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-213Tetrapyrrole methylase

Sequence similarities

Belongs to the diphthine synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    264
  • Mass (Da)
    29,828
  • Last updated
    2017-09-27 v1
  • Checksum
    A3981DC24E15B3C1
MAIYFIGLGLYDEKDITLKGLETARKCDLVFAEFYTSLLAGTTLDKVEELIGKPIRRLSREEVELHFERIVLSEAKEKDVAFLTAGDPMVATTHSDLRIRAKELGIESYVIHAPSIYSAIAVTGLQIYKFGKSATVAYPEKNWFPTSHYDVIKENMERNLHTMLFLDIKAEQNRYMTANEAMEILLQVEDMKRENVFTPDTLVVVLARAGSLNPTLKAGYVRDMIREDFGRQPHVMVVPGRLHIVEAEYLVAFAGAPKEILDGI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP021848
EMBL· GenBank· DDBJ
ASA78235.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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