A0A1W9WJQ0 · A0A1W9WJQ0_9GAMM
- ProteinGlucose-6-phosphate 1-dehydrogenase
- Genezwf
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids497 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
Catalytic activity
- D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH + H+
Pathway
Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 12-19 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: GATGNLAR | ||||||
Binding site | 46 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 88-89 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: DL | ||||||
Binding site | 149 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 179 | substrate | ||||
Sequence: H | ||||||
Binding site | 183 | substrate | ||||
Sequence: K | ||||||
Binding site | 217 | substrate | ||||
Sequence: E | ||||||
Binding site | 236 | substrate | ||||
Sequence: D | ||||||
Active site | 241 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 341 | substrate | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | glucose-6-phosphate dehydrogenase activity | |
Molecular Function | NADP binding | |
Biological Process | glucose metabolic process | |
Biological Process | pentose-phosphate shunt, oxidative branch |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlucose-6-phosphate 1-dehydrogenase
- EC number
- Short namesG6PD
Gene names
Organism names
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Thiotrichales > Thiotrichaceae > Candidatus Parabeggiatoa
Accessions
- Primary accessionA0A1W9WJQ0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 9-188 | Glucose-6-phosphate dehydrogenase NAD-binding | ||||
Sequence: VIFGATGNLARIKLMPALYHLEVAGRLPESTMILATGRRPWNRDKWISEVREMLLAKARDGLDENVFKQFQERLHYFEGDLSDPNMYPKMREFINNDPVFPQNVAFYMSIRPAEFGVVVQNLSEGGLLNEEHGWRRVVIEKPFGYDLESARALHQQFSRHLREEQVYRIDHYLGKGTVQN | ||||||
Domain | 190-487 | Glucose-6-phosphate dehydrogenase C-terminal | ||||
Sequence: LVFRFANLMLEPLWNRNYIDHVQITHSETLGVGSRADYYDSAGAMRDMIQSHLLQLLTLVAMEPPVSMEAEALRDEKVKVLKSIRPIPPNAVHAQTFRAQYTTGFVQDQKVKGYLQEDKVPKHSVTETYAAMKLFIDNWRWAGVPFYLRTGKRLAEAQSMISICFKQPPQQFFRTSQIQRMRSNWILLGIQPTECIKAEMTVKEPGLEMNTRKISMDASFRKEDDIQKEAYEELLLDVIKGDRSLFLRYDEVEYAWRVVEPILRVWAMERDYIPTYPAGSWGPKESRRLFEKEDQRWR |
Sequence similarities
Belongs to the glucose-6-phosphate dehydrogenase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length497
- Mass (Da)58,139
- Last updated2017-07-05 v1
- ChecksumF5DDD6FBC0B5D163