A0A1W6MTK4 · A0A1W6MTK4_9HYPH
- ProteinPalmitoyl-protein thioesterase ABHD10, mitochondrial
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids287 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
function
Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins. Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability. Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate.
Catalytic activity
- S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H+This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | hydrolase activity, hydrolyzing O-glycosyl compounds |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePalmitoyl-protein thioesterase ABHD10, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Methylocystaceae > Methylocystis
Accessions
- Primary accessionA0A1W6MTK4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 54-268 | AB hydrolase-1 | ||||
Sequence: ASFLDARAAASGRALLRFDYSGHGESAFDLPGGRFEDGSLGDWLEQSLALFLTSTQGPQLVIGSSMGSWIALRLAQRLEAIGEAKRLLGLVLIAPAVDFTEELILPTLSEAERRELDEGSGEIIRPAGRDGSPPLTRRLLEEGRRHLLLGGQMRSYAPVRILQGVRDEAVPWRHAFRVAEKLAADPVVVTLVAEGDHRLSRPEDLEQLAQTLERL |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length287
- Mass (Da)31,046
- Last updated2017-07-05 v1
- Checksum4ADAD7D2DAFFCCAA
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP019948 EMBL· GenBank· DDBJ | ARN80940.1 EMBL· GenBank· DDBJ | Genomic DNA |