A0A1W6MSE5 · A0A1W6MSE5_9HYPH
- ProteinPorphobilinogen deaminase
- GenehemC
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids308 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
Miscellaneous
The porphobilinogen subunits are added to the dipyrromethane group.
Catalytic activity
- 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH4+
Cofactor
Note: Binds 1 dipyrromethane group covalently.
Pathway
Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | hydroxymethylbilane synthase activity | |
Biological Process | peptidyl-pyrromethane cofactor linkage | |
Biological Process | protoporphyrinogen IX biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePorphobilinogen deaminase
- EC number
- Short namesPBG
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Methylocystaceae > Methylocystis
Accessions
- Primary accessionA0A1W6MSE5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 244 | S-(dipyrrolylmethanemethyl)cysteine | ||||
Sequence: C |
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 6-214 | Porphobilinogen deaminase N-terminal | ||||
Sequence: LTIGTRGSPLALAQTQETRARLAAAHGVAPDHFRIVVIRTSGDAIQDRALAEAGGKGLFTRELDLALIAREIDFAVHSSKDLPTELPEEIAIAGYLPREDPRDAFIGRGGARLVELPEGAVIGTASLRRAAQVKRFRADLKTVLLRGNVETRLAKVESGAVDGTLLALAGLRRLGLESRATEILPLDAFLPAAGQGAIGIACRASDDAT | ||||||
Domain | 231-297 | Porphobilinogen deaminase C-terminal | ||||
Sequence: NAERAFLKALDGSCRTPIAGLAVVEGDSLRFHGEALQSDGGCTFAARQEGGVAQAASLGAGAAREIL |
Sequence similarities
Belongs to the HMBS family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length308
- Mass (Da)31,867
- Last updated2017-07-05 v1
- ChecksumEA46864E37EE6182
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP019948 EMBL· GenBank· DDBJ | ARN80533.1 EMBL· GenBank· DDBJ | Genomic DNA |