A0A1W6MSE5 · A0A1W6MSE5_9HYPH

  • Protein
    Porphobilinogen deaminase
  • Gene
    hemC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.

Miscellaneous

The porphobilinogen subunits are added to the dipyrromethane group.

Catalytic activity

Cofactor

dipyrromethane (UniProtKB | Rhea| CHEBI:60342 )

Note: Binds 1 dipyrromethane group covalently.

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionhydroxymethylbilane synthase activity
Biological Processpeptidyl-pyrromethane cofactor linkage
Biological Processprotoporphyrinogen IX biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Porphobilinogen deaminase
  • EC number
  • Short names
    PBG
  • Alternative names
    • Hydroxymethylbilane synthase
      (HMBS
      )
    • Pre-uroporphyrinogen synthase

Gene names

    • Name
      hemC
    • ORF names
      B1812_05030

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • S285
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Methylocystaceae > Methylocystis

Accessions

  • Primary accession
    A0A1W6MSE5

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue244S-(dipyrrolylmethanemethyl)cysteine

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-214Porphobilinogen deaminase N-terminal
Domain231-297Porphobilinogen deaminase C-terminal

Sequence similarities

Belongs to the HMBS family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    308
  • Mass (Da)
    31,867
  • Last updated
    2017-07-05 v1
  • Checksum
    EA46864E37EE6182
MSLPSLTIGTRGSPLALAQTQETRARLAAAHGVAPDHFRIVVIRTSGDAIQDRALAEAGGKGLFTRELDLALIAREIDFAVHSSKDLPTELPEEIAIAGYLPREDPRDAFIGRGGARLVELPEGAVIGTASLRRAAQVKRFRADLKTVLLRGNVETRLAKVESGAVDGTLLALAGLRRLGLESRATEILPLDAFLPAAGQGAIGIACRASDDATYAALAPILDAATCAALNAERAFLKALDGSCRTPIAGLAVVEGDSLRFHGEALQSDGGCTFAARQEGGVAQAASLGAGAAREILRRLPGGVASLS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP019948
EMBL· GenBank· DDBJ
ARN80533.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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