A0A1W2GKW9 · A0A1W2GKW9_REIFA

Function

function

Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

NAD+ (UniProtKB | Rhea| CHEBI:57540 )

Note: Binds 1 NAD+ per subunit.

Pathway

Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site57-58NAD+ (UniProtKB | ChEBI)
Binding site135NAD+ (UniProtKB | ChEBI)
Binding site181-183NAD+ (UniProtKB | ChEBI)
Binding site201NAD+ (UniProtKB | ChEBI)
Binding site206NAD+ (UniProtKB | ChEBI)
Binding site268-272NAD+ (UniProtKB | ChEBI)
Binding site278-279NAD+ (UniProtKB | ChEBI)
Binding site327NAD+ (UniProtKB | ChEBI)
Active site415
Binding site497NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionurocanate hydratase activity
Biological ProcessL-histidine catabolic process to glutamate and formamide
Biological ProcessL-histidine catabolic process to glutamate and formate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Urocanate hydratase
  • EC number
  • Short names
    Urocanase
  • Alternative names
    • Imidazolonepropionate hydrolase

Gene names

    • Name
      hutU
    • ORF names
      SAMN04488029_3293

Organism names

  • Taxonomic identifier
  • Strain
    • DSM 26133
  • Taxonomic lineage
    Bacteria > Bacteroidota > Cytophagia > Cytophagales > Reichenbachiellaceae > Reichenbachiella

Accessions

  • Primary accession
    A0A1W2GKW9

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain17-142Urocanase N-terminal
Domain145-353Urocanase Rossmann-like
Domain356-549Urocanase C-terminal

Sequence similarities

Belongs to the urocanase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    558
  • Mass (Da)
    61,350
  • Last updated
    2017-06-07 v1
  • Checksum
    539F35FB1B76E822
MRYSEFIKQYASHPNYKAPTGSQLHAKSWQTESALRMLLNNLDAEVAEDPSELVVYGGTGQAARNVESLQKIIELLLKLENDESLLVQSGKPVGIVRTHAEAPRVLIANSNLVPAWSNWEHFQSLKERGLMMYGQMTAGSWIYIGSQGILQGTYETFVACGEKHFGGSLKGKLVVTAGLGGMGGAQPLAATMAGATFLGADIDPTRIQKRLDTKYIDRMTHSYEEARDWVMEAKAKGENLSVGLVADAGDMLEQLIADGIVPEVLTDQTSAHDPVFGYVPNGMSLEEAVDLRKKDQVKYKDLSLKSMARHVGLMLDLQKKGSKTFDYGNNIREFARQGGEPNAFDFNGFVPEYVRPLFCEGKGPFRWAALSGDPEDIYVTDQALIEAFPENKHMINWLQEAQKKVSFQGLPCRICWLGMGEREKAGLIFNDLVKTGKVKAPIVIGRDHLDCGSVASPNRETEGMKDGTDAVSDWPLLNLMSNATGGATWISFHHGGGVGMGYSQHAGMVVLADGTERAEKCLKRVLHNDPAMGIFRHHDAGYDKASKFADDFDLNVWK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FWYF01000003
EMBL· GenBank· DDBJ
SMD37204.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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