A0A1V6EPE7 · A0A1V6EPE7_9BACT

Function

function

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site45ATP (UniProtKB | ChEBI)
Binding site52-54ATP (UniProtKB | ChEBI)
Binding site94ATP (UniProtKB | ChEBI)
Binding site99ATP (UniProtKB | ChEBI)
Binding site191Mg2+ (UniProtKB | ChEBI)
Binding site205Mg2+ (UniProtKB | ChEBI)
Binding site256substrate; ligand shared with subunit alpha
Binding site313-315substrate; ligand shared with subunit alpha

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmagnesium ion binding
Molecular Functionsuccinate-CoA ligase (ADP-forming) activity
Molecular Functionsuccinate-CoA ligase (GDP-forming) activity
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Succinate--CoA ligase [ADP-forming] subunit beta
  • EC number
  • Alternative names
    • Succinyl-CoA synthetase subunit beta
      (SCS-beta
      )

Gene names

    • Name
      sucC
    • ORF names
      BWX77_00759

Organism names

Accessions

  • Primary accession
    A0A1V6EPE7

Proteomes

Subcellular Location

Interaction

Subunit

Heterotetramer of two alpha and two beta subunits.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-219ATP-grasp

Sequence similarities

Belongs to the succinate/malate CoA ligase beta subunit family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    380
  • Mass (Da)
    40,696
  • Last updated
    2017-06-07 v1
  • Checksum
    548412E6992254AD
MKIHEHQAKSLFSDYGIPVPREMLCSDTGAVPGAVEQLGLPLVVKAQVLTGGRGKAGGVKLARSADEASAAAKQILGMDIKGYRVNKVLLAEAVNIQAEYYIALTIDRNSKSVLLMASAEGGVEIEEVAKTRPQAIHKLSIDPLLGLTAFLARRIAFALFKDIALVKQAASIFQKMYKLLIETDASLVEINPLVRTGEGQLLALDAKMNFDDNALYRHPNIAALLEADENELKELDAKEKGLSYIALDGNIGCMVNGAGLAMATMDLIKHYGGSPANFLDIGGSSNPQKVVDAMEIILSEKKVKSLMINIFGGITRCDDVARGLLEALEELQVDIPIVVNLSGTNAKEGLELLGGSSLHVVHSMREAAQKAIQLSQLSQD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MWEC01000134
EMBL· GenBank· DDBJ
OQC03272.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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