A0A1U2BW66 · A0A1U2BW66_9MYCO

Function

function

Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s2U34.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Features

Showing features for binding site, active site, site.

135650100150200250300350
TypeIDPosition(s)Description
Binding site6-13ATP (UniProtKB | ChEBI)
Binding site32ATP (UniProtKB | ChEBI)
Active site101Nucleophile
Binding site125ATP (UniProtKB | ChEBI)
Site126Interaction with tRNA
Active site193Cysteine persulfide intermediate
Site333Interaction with tRNA

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmethyltransferase activity
Molecular FunctiontRNA binding
Molecular FunctiontRNA-uridine 2-sulfurtransferase activity
Biological Processmethylation
Biological ProcesstRNA modification

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA-specific 2-thiouridylase MnmA
  • EC number

Gene names

    • Name
      mnmA
    • ORF names
      SAMEA2259716_00144

Organism names

Accessions

  • Primary accession
    A0A1U2BW66

Proteomes

Subcellular Location

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region143-145Interaction with tRNA
Domain202-267tRNA-specific 2-thiouridylase MnmA-like central
Domain280-353tRNA-specific 2-thiouridylase MnmA-like C-terminal

Sequence similarities

Belongs to the MnmA/TRMU family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    356
  • Mass (Da)
    37,918
  • Last updated
    2017-05-10 v1
  • Checksum
    21BD9DA69AEFC7FB
MKILAAMSGGVDSSVAAARMVDAGHEVVGVHLALSAAPGTLRTGSRGCCSKEDAADARRVADMLGIPFYVWDFADRFKEDVIDDFVEAYAEGRTPNPCVKCNEKIKFAALADRAVALGFDAVATGHYARLQDGRLRRAVDADKDQSYVLGVLTPEQLSRAMFPVGDSPKPDIRAEAEQRGLLVANKPDSHDICFIPSGDTQAFLGARIGVRRGNVVDADGSVLATHAGVHEFTIGQRKGLGLVGPAADGRPRYVTSIDAETATVRVGTVEDLEIWEFGGEPVVWTSGRVPVQPIECQVQVRAHGSVVDAVVEPGAERIHVRLRTALRGVAPGQTVVLYRPDAEGDEVLGSAVITRD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FVGW01000001
EMBL· GenBank· DDBJ
SKL34609.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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