A0A1R0GGJ2 · A0A1R0GGJ2_9PSED

Function

function

Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 Mn2+ ions per subunit in a binuclear metal center.

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 4/6.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site7Mn2+ 1 (UniProtKB | ChEBI)
Binding site9Mn2+ 1 (UniProtKB | ChEBI)
Binding site40Mn2+ 1 (UniProtKB | ChEBI)
Binding site40Mn2+ 2 (UniProtKB | ChEBI)
Binding site78Mn2+ 2 (UniProtKB | ChEBI)
Binding site78-79substrate
Binding site113Mn2+ 2 (UniProtKB | ChEBI)
Binding site121substrate
Binding site159substrate
Binding site166substrate
Binding site194Mn2+ 2 (UniProtKB | ChEBI)
Binding site194substrate
Binding site196Mn2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentextrinsic component of plasma membrane
Molecular Functionmanganese ion binding
Molecular FunctionUDP-2,3-diacylglucosamine hydrolase activity
Biological Processlipid A biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UDP-2,3-diacylglucosamine hydrolase
  • EC number
  • Alternative names
    • UDP-2,3-diacylglucosamine diphosphatase

Gene names

    • Name
      lpxH
    • ORF names
      AU074_19880

Organism names

  • Taxonomic identifier
  • Strain
    • ATCC PTA-122608
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A1R0GGJ2

Proteomes

Subcellular Location

Cell inner membrane
; Peripheral membrane protein

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-198Calcineurin-like phosphoesterase

Sequence similarities

Belongs to the LpxH family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    249
  • Mass (Da)
    27,994
  • Last updated
    2017-04-12 v1
  • Checksum
    F32A0B1A3F1E8187
MILLISDLHLEEERPDITRAFLDLLNGRARSAQALYILGDFFEAWIGDDGMTPFQRSICEALRELSDSGTQIFIMHGNRDFLIGKAFCKAAGATLLKDPSVVQLAGEPVLLMHGDSLCTRDLGYMKLRRILRNPITLFILRHLPLRTRHKLARKLRSESSAQVRMKANDIVDVTPEEVPRVMQAFGVRTLVHGHTHRPAIHKLQIGEQAAKRIVLGDWDKQGWALQVDEQGFQLAAFDFVNPQLALPGA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LPNO01000006
EMBL· GenBank· DDBJ
OLY76009.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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