A0A1M7T6N4 · A0A1M7T6N4_9BACT

Function

function

Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N1-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site5Nucleophile
Binding site246[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site293Mg2+ (UniProtKB | ChEBI)
Binding site355Mg2+ (UniProtKB | ChEBI)
Binding site356Mg2+ (UniProtKB | ChEBI)
Binding site392[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site442[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site445[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionamidophosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Biological Process'de novo' IMP biosynthetic process
Biological Processglutamine metabolic process
Biological Processpurine nucleobase biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Amidophosphoribosyltransferase
  • EC number
  • Short names
    ATase
  • Alternative names
    • Glutamine phosphoribosylpyrophosphate amidotransferase
      (GPATase
      )

Gene names

    • Name
      purF
    • ORF names
      SAMN02745728_01632

Organism names

  • Taxonomic identifier
  • Strain
    • DSM 11393
  • Taxonomic lineage
    Bacteria > Thermodesulfobacteriota > Desulfovibrionia > Desulfovibrionales > Desulfovibrionaceae > Desulfovibrio

Accessions

  • Primary accession
    A0A1M7T6N4

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-225Glutamine amidotransferase type-2

Sequence similarities

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    455
  • Mass (Da)
    50,996
  • Last updated
    2017-03-15 v1
  • Checksum
    800B5EB1A8DEA78B
MKEYCGIMGVYNHTEATKLVYFGLYAQQHRGQESAGITAWDGTKISDKRVFGLASSNFTENDFISNLKGHIAIGHVSSKPEKQAFLSCVDPFIIKYKGTTMVAALNGGLTNSQELRDLLENDGGVLRSDSDSELFLHLIVRNLHTMSEEQAVLAAARQLKGAFSFLLMIKNRIYVVRDTFGFKPLALAQYGESIIIASETCAFDLIEAKYIRDVEPGEVLIIDEKNMRSLWIDEDIPTEQRKRAHCIFEFVYSARPDSLIFGQNVYMVRQALGMKLAQEHPVDADLVLPFPDSGIYSAVGFAKGSGLPYEHAMIRNHYVGRTFIQPTQNMRDFSVRIKINPVREVIEGKRIVIVDDSIVRGTTMDTRVKKLRELGAKEIHCRISSPKVIASCPYGVDFASKGELIASKYSTDEIRQKLGLDSLGYLSIPGMLETLNRPKDYCTACFDANYPLKWS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FRDI01000007
EMBL· GenBank· DDBJ
SHN66393.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp