A0A1M3PAL8 · A0A1M3PAL8_9SPHN
- ProteinAcetolactate synthase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids581 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Catalytic activity
- 2 pyruvate + H+ = (2S)-2-acetolactate + CO2
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 Mg2+ ion per subunit.
Note: Binds 1 thiamine pyrophosphate per subunit.
Pathway
Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.
Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | acetolactate synthase complex | |
Molecular Function | acetolactate synthase activity | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | thiamine pyrophosphate binding | |
Biological Process | isoleucine biosynthetic process | |
Biological Process | valine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAcetolactate synthase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Sphingomonadales > Sphingomonadaceae > Sphingobium
Accessions
- Primary accessionA0A1M3PAL8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 5-120 | Thiamine pyrophosphate enzyme N-terminal TPP-binding | ||||
Sequence: SGADILVQCLVDLGVDTVFGYPGGAVLPIYDTIYEHPTIKHVLVRHEQAAAHAAEGYARSTGKPGVVLVTSGPGATNAITGITDALMDSIPIVVITGQVATHLIGSDAFQEADTVG | ||||||
Domain | 194-331 | Thiamine pyrophosphate enzyme central | ||||
Sequence: IARAADLIAAAERPIIYSGGGIINSGPEASAALRALAEMTGAPVTSTLMGLGAFPASSPQWLGMLGMHGTYESNWAMNQADLILCLGARFDDRVTGRLDAFAPNSKKIHVDIDRSSINKIIPVDIPIVADSGRAIEAL | ||||||
Domain | 394-541 | Thiamine pyrophosphate enzyme TPP-binding | ||||
Sequence: VGQHQMWAAQHFHFDAPNKWLTSGGLGTMGYGFPAAIGAQLGNPDALVIDIAGDASIQMNIQELGTVIQYGLPVKIFILNNEYMGMVRQWQELTYESRYSHSYSDSLPNFVKLAEAYGARGIRIETRDQLEAGIAEMIAHPGPVVVDC |
Sequence similarities
Belongs to the TPP enzyme family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length581
- Mass (Da)62,747
- Last updated2017-03-15 v1
- ChecksumB802DDF4195F16A4