A0A1L5BTC1 · LINB_SPHIB

Function

function

Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity).
Is involved in the degradation of the important environmental pollutant gamma-hexachlorocyclohexane (gamma-HCH or lindane) as it also catalyzes conversion of 1,3,4,6-tetrachloro-1,4-cyclohexadiene (1,4-TCDN) to 2,5-dichloro-2,5-cyclohexadiene-1,4-diol (2,5-DDOL) via the intermediate 2,4,5-trichloro-2,5-cyclohexadiene-1-ol (2,4,5-DNOL) (By similarity) (PubMed:12450824).

Catalytic activity

Pathway

Xenobiotic degradation; gamma-hexachlorocyclohexane degradation.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site108Nucleophile
Active site132Proton donor
Active site272Proton acceptor

GO annotations

AspectTerm
Cellular Componentperiplasmic space
Molecular Functionhaloalkane dehalogenase activity
Biological Processresponse to toxic substance

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Haloalkane dehalogenase
  • EC number
  • Alternative names
    • 1,3,4,6-tetrachloro-1,4-cyclohexadiene halidohydrolase
      (1,4-TCDN halidohydrolase
      )

Gene names

    • Name
      linB
    • ORF names
      SIDU_17345

Organism names

Accessions

  • Primary accession
    A0A1L5BTC1
  • Secondary accessions
    • P51698

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004449401-296Haloalkane dehalogenase

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain31-155AB hydrolase-1

Sequence similarities

Belongs to the haloalkane dehalogenase family. Type 2 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    296
  • Mass (Da)
    33,230
  • Last updated
    2017-03-15 v1
  • Checksum
    B14249854546F602
MSLGAKPFGEKKFIEIKGRRMAYIDEGTGDPILFQHGNPTSSYLWRNIMPHCAGLGRLIACDLIGMGDSDKLDPSGPERYTYAEHRDYLDALWEALDLGDRVVLVVHDWGSVLGFDWARRHRERVQGIAYMEAVTMPLEWADFPEQDRDLFQAFRSQAGEELVLQDNVFVEQVLPGLILRPLSEAEMAAYREPFLAAGEARRPTLSWPRQIPIAGTPADVVAIARDYAGWLSESPIPKLFINAEPGHLTTGRIRDFCRTWPNQTEITVAGAHFIQEDSPDEIGAAIAAFVRRLRPA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY150581
EMBL· GenBank· DDBJ
AAN64241.1
EMBL· GenBank· DDBJ
Genomic DNA
CP013070
EMBL· GenBank· DDBJ
APL96138.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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