A0A1L1YNT9 · A0A1L1YNT9_9FLOR

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    cox1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      cox1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 107P
  • Taxonomic lineage
    Eukaryota > Rhodophyta > Florideophyceae > Rhodymeniophycidae > Gracilariales > Gracilariaceae > Gracilaria

Accessions

  • Primary accession
    A0A1L1YNT9

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-49Helical
Transmembrane70-92Helical
Transmembrane112-137Helical
Transmembrane149-176Helical
Transmembrane196-220Helical
Transmembrane232-256Helical
Transmembrane268-291Helical
Transmembrane303-324Helical
Transmembrane336-361Helical
Transmembrane373-391Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-428Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    428
  • Mass (Da)
    47,230
  • Last updated
    2017-03-15 v1
  • Checksum
    D0866E93F556BEFB
IRMELAQPGNQLLLGNHQIYNVLITAHAFLMIFFMVMPVMIGGFGNWLVPIMIGSPDMAFPRLNNISFWLLPPSLCLLLASAVVEVGVGTGWTVYPPLSSIQSHSGGAVDLAIFSLHISGASSILGAINFISTILNMRNPGQSLYRMPLFVWSIFITAFLLLLAVPVLAGAITMLLTDRNFNTAFFDPAGGGDPVLYQHLFWFFGHPEVYILILPGFGMISHIVATFSRKPVFGYIGMVYAMVSIGVLGFIVWAHHMYTVGLDVDTRAYFTAATMIIAVPTGIKIFSWVATMWEGSLYFKTPMLFATGFIFLFTIGGLTGIVLANSGLDISLHDTYYVVAHFHYVLSMGAVFAIFAGFYYWFGKITGVQYPEVLGKIHFWSTFIGVNLTFMPMHFLGLAGMPRRIPDYPDAYAGWNLIASYGSYVALF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue428

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KP010060
EMBL· GenBank· DDBJ
AKN80306.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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