A0A1J5NMB4 · A0A1J5NMB4_MOOTH
- ProteinHomoserine O-acetyltransferase
- GenemetX
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids374 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
Catalytic activity
- L-homoserine + acetyl-CoA = O-acetyl-L-homoserine + CoA
Pathway
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 151 | Nucleophile | ||||
Sequence: S | ||||||
Binding site | 220 | substrate | ||||
Sequence: R | ||||||
Active site | 314 | |||||
Sequence: D | ||||||
Active site | 347 | |||||
Sequence: H | ||||||
Binding site | 348 | substrate | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | homoserine O-acetyltransferase activity | |
Biological Process | homoserine metabolic process | |
Biological Process | methionine biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHomoserine O-acetyltransferase
- EC number
- Short namesHAT
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Clostridia > Moorellales > Moorellaceae > Moorella
Accessions
- Primary accessionA0A1J5NMB4
Proteomes
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 45-351 | AB hydrolase-1 | ||||
Sequence: NAILVLHALTGNAHIAGRNFPDERYPGWWDPLVGPGRALDTRRYFIVCANVLGSCYGTTGPASINPATGKPYGMDFPAITIRDMVRVQKILLDYLGVKRLVAAIGGSMGGMQVLEWGFLYPQMLDAIIPIATCGRTTPMQIAFHHVQREAIYADPGWQGGNYYGTAGPRRGLALARQIGIITYKSDPSWNMKFGRNLVDPREYFRMEGQFEVESYLAYQGRKLVDRFDANSYLYLTKAVDLHDVSQGRGSYNEVWQGFPCPCLGIGISSDFLFPPYQVQEIVRMINDGGGHARYAEIDSPYGHDAFL |
Sequence similarities
Belongs to the AB hydrolase superfamily. MetX family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length374
- Mass (Da)41,650
- Last updated2017-02-15 v1
- Checksum9032DB5002EA5A9F
Keywords
- Technical term