A0A1J1HUS3 · A0A1J1HUS3_9DIPT
- ProteinSphingomyelin phosphodiesterase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids701 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Converts sphingomyelin to ceramide.
Catalytic activity
- a sphingomyelin + H2O = an N-acylsphing-4-enine + H+ + phosphocholine
Cofactor
Note: Binds 2 Zn2+ ions per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 261 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 263 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 335 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 335 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 375 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 483 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 517 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 519 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Cellular Component | lysosome | |
Molecular Function | acid sphingomyelin phosphodiesterase activity | |
Molecular Function | hydrolase activity, acting on glycosyl bonds | |
Molecular Function | metal ion binding | |
Biological Process | ceramide biosynthetic process | |
Biological Process | sphingomyelin catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSphingomyelin phosphodiesterase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Chironomoidea > Chironomidae > Clunio
Accessions
- Primary accessionA0A1J1HUS3
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-20 | |||||
Sequence: MKRSFLLVATLSLLVGSINS | ||||||
Chain | PRO_5012113946 | 21-701 | Sphingomyelin phosphodiesterase | |||
Sequence: SPFKKANTNNRRRQRSSSVWKQPEDNWNITTIPRSVHPHLENKNYTHSLPAPGHIIYRTIDSDERLLMRFHEIKNNASARTLWGKSDSSDHHYSPFFDKALKLLNLQQVAFEIENSVMSKMSCTACKAGASLLQNYIKSGKSKEEIIKTIFQYCVNLRIQSAQVCEGVSQLFGGEVIYVLKRTNLGADEICSFIIGEACGDIYNPYHEWEVELPPIPKPIAHELPIPKEGAPSFKVLHLSDTHYDPYYEPGANAECKEGILCCRHSSGRPTTPNAAAGKWGDYRKCDMPKRSLDHMYQHIASTHHDIDYILWTGDLPPHDIWNQTKEENLKILKETVKQMSEMFPGVPIFPALGNHESAPVNSFPPPYVKQVDSSIAWLYDALDIQWRKWLPASVSHTVRRGAFYSVLVRPGFRIISLNMNYCNNLNWWLLLNSTDPATELQWFIYELQSAEFLNEKVHVIGHIPPGHSDCLKVWSRNYYKIVQRYENTITAQFFGHTHFDEFEVFYDLEDISRATRYRIYYVDGDHDASTRLVIDHETWIMNLKEANLYDFPIYYKLYSARAAYNMKALRPNDWDELINTLTDDQDKFDLYYKNYWKVSPVRPACDADCRKRLLCDAKSGRSHDRKFFCAEVESKIDSSNNGWRSWIYKGISFSNKKKLFNITAYQFLTNEVGQEFHPAT | ||||||
Disulfide bond | 143↔219 | |||||
Sequence: CTACKAGASLLQNYIKSGKSKEEIIKTIFQYCVNLRIQSAQVCEGVSQLFGGEVIYVLKRTNLGADEICSFIIGEAC | ||||||
Disulfide bond | 146↔211 | |||||
Sequence: CKAGASLLQNYIKSGKSKEEIIKTIFQYCVNLRIQSAQVCEGVSQLFGGEVIYVLKRTNLGADEIC | ||||||
Disulfide bond | 174↔185 | |||||
Sequence: CVNLRIQSAQVC | ||||||
Disulfide bond | 276↔282 | |||||
Sequence: CKEGILC | ||||||
Disulfide bond | 283↔306 | |||||
Sequence: CRHSSGRPTTPNAAAGKWGDYRKC | ||||||
Disulfide bond | 443↔491 | |||||
Sequence: CNNLNWWLLLNSTDPATELQWFIYELQSAEFLNEKVHVIGHIPPGHSDC | ||||||
Disulfide bond | 626↔630 | |||||
Sequence: CDADC | ||||||
Disulfide bond | 636↔650 | |||||
Sequence: CDAKSGRSHDRKFFC |
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 139-223 | Saposin B-type | ||||
Sequence: SKMSCTACKAGASLLQNYIKSGKSKEEIIKTIFQYCVNLRIQSAQVCEGVSQLFGGEVIYVLKRTNLGADEICSFIIGEACGDIY |
Sequence similarities
Belongs to the acid sphingomyelinase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length701
- Mass (Da)81,114
- Last updated2017-02-15 v1
- Checksum0ECC64230DDDA41A
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1J1I0B1 | A0A1J1I0B1_9DIPT | CLUMA_CG005448 | 681 |
Keywords
- Technical term