A0A1J1HUS3 · A0A1J1HUS3_9DIPT

  • Protein
    Sphingomyelin phosphodiesterase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Converts sphingomyelin to ceramide.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Features

Showing features for binding site.

170150100150200250300350400450500550600650700
TypeIDPosition(s)Description
Binding site261Zn2+ 1 (UniProtKB | ChEBI)
Binding site263Zn2+ 1 (UniProtKB | ChEBI)
Binding site335Zn2+ 2 (UniProtKB | ChEBI)
Binding site335Zn2+ 1 (UniProtKB | ChEBI)
Binding site375Zn2+ 2 (UniProtKB | ChEBI)
Binding site483Zn2+ 2 (UniProtKB | ChEBI)
Binding site517Zn2+ 2 (UniProtKB | ChEBI)
Binding site519Zn2+ 1 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Cellular Componentlysosome
Molecular Functionacid sphingomyelin phosphodiesterase activity
Molecular Functionhydrolase activity, acting on glycosyl bonds
Molecular Functionmetal ion binding
Biological Processceramide biosynthetic process
Biological Processsphingomyelin catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sphingomyelin phosphodiesterase
  • EC number

Gene names

    • ORF names
      CLUMA_CG005448

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Chironomoidea > Chironomidae > Clunio

Accessions

  • Primary accession
    A0A1J1HUS3

Proteomes

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-20
ChainPRO_501211394621-701Sphingomyelin phosphodiesterase
Disulfide bond143↔219
Disulfide bond146↔211
Disulfide bond174↔185
Disulfide bond276↔282
Disulfide bond283↔306
Disulfide bond443↔491
Disulfide bond626↔630
Disulfide bond636↔650

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain139-223Saposin B-type

Sequence similarities

Belongs to the acid sphingomyelinase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    701
  • Mass (Da)
    81,114
  • Last updated
    2017-02-15 v1
  • Checksum
    0ECC64230DDDA41A
MKRSFLLVATLSLLVGSINSSPFKKANTNNRRRQRSSSVWKQPEDNWNITTIPRSVHPHLENKNYTHSLPAPGHIIYRTIDSDERLLMRFHEIKNNASARTLWGKSDSSDHHYSPFFDKALKLLNLQQVAFEIENSVMSKMSCTACKAGASLLQNYIKSGKSKEEIIKTIFQYCVNLRIQSAQVCEGVSQLFGGEVIYVLKRTNLGADEICSFIIGEACGDIYNPYHEWEVELPPIPKPIAHELPIPKEGAPSFKVLHLSDTHYDPYYEPGANAECKEGILCCRHSSGRPTTPNAAAGKWGDYRKCDMPKRSLDHMYQHIASTHHDIDYILWTGDLPPHDIWNQTKEENLKILKETVKQMSEMFPGVPIFPALGNHESAPVNSFPPPYVKQVDSSIAWLYDALDIQWRKWLPASVSHTVRRGAFYSVLVRPGFRIISLNMNYCNNLNWWLLLNSTDPATELQWFIYELQSAEFLNEKVHVIGHIPPGHSDCLKVWSRNYYKIVQRYENTITAQFFGHTHFDEFEVFYDLEDISRATRYRIYYVDGDHDASTRLVIDHETWIMNLKEANLYDFPIYYKLYSARAAYNMKALRPNDWDELINTLTDDQDKFDLYYKNYWKVSPVRPACDADCRKRLLCDAKSGRSHDRKFFCAEVESKIDSSNNGWRSWIYKGISFSNKKKLFNITAYQFLTNEVGQEFHPAT

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1J1I0B1A0A1J1I0B1_9DIPTCLUMA_CG005448681

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CVRI01000021
EMBL· GenBank· DDBJ
CRK91824.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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