A0A1I1XM44 · A0A1I1XM44_9GAMM

Function

function

Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

Pathway

Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site23[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site27[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site30[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functioncyclase activity
Molecular Functioniron ion binding
Molecular Functionoxidoreductase activity
Molecular FunctionS-adenosyl-L-methionine binding
Biological Processpyrroloquinoline quinone biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    PqqA peptide cyclase
  • EC number
  • Alternative names
    • Coenzyme PQQ synthesis protein E

Gene names

    • Name
      pqqE
    • ORF names
      SAMN04487869_10338

Organism names

  • Taxonomic identifier
  • Strain
    • DSM 26671
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Marinobacteraceae > Marinobacter

Accessions

  • Primary accession
    A0A1I1XM44

Proteomes

Interaction

Subunit

Interacts with PqqD. The interaction is necessary for activity of PqqE.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-228Radical SAM core

Sequence similarities

Belongs to the radical SAM superfamily. PqqE family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    378
  • Mass (Da)
    42,362
  • Last updated
    2017-11-22 v1
  • Checksum
    16F75B8C8CBE7D00
MSTTNPHNAGPPLWLLAELTYRCPLQCPYCSNPLDFAQTQQELTTEEWVSVLRQGRTMGAAQLGFSGGEPLVRQDLAELIAEARHLGYYTNLITSGLGLTEAKVDAFAEAGLDHIQVSFQASDPELNNAVAGSRKAFDQKLALARAVKEAGYPMVLNFVIHRHNIHQMNDIMDLCERLGADYVELATCQYYGWAFENREGLMPSKAQLVKAEQEVNRYRERLQQSGSAMKLIFVTPDYYEERPKACMNGWGNLFLTVAPDGTALPCHSARLLPIDFPNVRDMDLQNIWYDSPGFNHYRGDTWMPEPCRSCDEKEKDFGGCRCQAYLLTGKADNADPVCSKSSYHDRILAARKAADHATAGLTELVYRNADNSRLFFRG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FONF01000003
EMBL· GenBank· DDBJ
SFE08386.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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