A0A1I1XM44 · A0A1I1XM44_9GAMM
- ProteinPqqA peptide cyclase
- GenepqqE
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids378 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).
Catalytic activity
- [PQQ precursor protein] + S-adenosyl-L-methionine = E-Y cross-linked-[PQQ precursor protein] + 5'-deoxyadenosine + L-methionine + H+
Cofactor
Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
Pathway
Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | cyclase activity | |
Molecular Function | iron ion binding | |
Molecular Function | oxidoreductase activity | |
Molecular Function | S-adenosyl-L-methionine binding | |
Biological Process | pyrroloquinoline quinone biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePqqA peptide cyclase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Marinobacteraceae > Marinobacter
Accessions
- Primary accessionA0A1I1XM44
Proteomes
Interaction
Subunit
Interacts with PqqD. The interaction is necessary for activity of PqqE.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 9-228 | Radical SAM core | ||||
Sequence: AGPPLWLLAELTYRCPLQCPYCSNPLDFAQTQQELTTEEWVSVLRQGRTMGAAQLGFSGGEPLVRQDLAELIAEARHLGYYTNLITSGLGLTEAKVDAFAEAGLDHIQVSFQASDPELNNAVAGSRKAFDQKLALARAVKEAGYPMVLNFVIHRHNIHQMNDIMDLCERLGADYVELATCQYYGWAFENREGLMPSKAQLVKAEQEVNRYRERLQQSGSA |
Sequence similarities
Belongs to the radical SAM superfamily. PqqE family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length378
- Mass (Da)42,362
- Last updated2017-11-22 v1
- Checksum16F75B8C8CBE7D00