A0A1G3Y0H3 · A0A1G3Y0H3_9BACT

Function

function

Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site76Zn2+ (UniProtKB | ChEBI)
Binding site233Zn2+ (UniProtKB | ChEBI)
Binding site237Zn2+ (UniProtKB | ChEBI)
Active site260Proton donor

GO annotations

AspectTerm
Molecular Functionmetal ion binding
Molecular FunctionUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Molecular FunctionUDP-3-O-acyl-N-acetylglucosamine deacetylase activity
Biological Processlipid A biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UDP-3-O-acyl-N-acetylglucosamine deacetylase
  • EC number
  • Short names
    UDP-3-O-acyl-GlcNAc deacetylase
  • Alternative names
    • UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase

Gene names

    • Name
      lpxC
    • ORF names
      A2Z47_08185

Organism names

Accessions

  • Primary accession
    A0A1G3Y0H3

Proteomes

Family & Domains

Sequence similarities

Belongs to the LpxC family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    292
  • Mass (Da)
    32,576
  • Last updated
    2017-02-15 v1
  • Checksum
    49409F5EC9F25767
MRLQRTLKREVSFEGIGLHTGRHSKVRLRPASRDTGIIFIRTDKDLAIRASINSVTDTAFSTTLGYNGIKIRTVEHILAALYGLGIDNLFIEINGPEIPILDGSSIELTNLILKGEIAKQSKKRPYIRITNPVVINDGYAKIVALPHNGRRITYMIHFNHHLLGEQKLSLELTEENFVIEVAPARTFGFLKDVDYLKANGFARGGSFDNVIILGESGILNSSGLRFKDEFVRHKILDMIGDLSLAGFPIYGHIIASKSGHTTNLKFLKKLLSHPDCWELISEVSQQPVSVYT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MIDI01000122
EMBL· GenBank· DDBJ
OHE58131.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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