A0A1G0JJ69 · A0A1G0JJ69_9GAMM

Function

function

Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

tRNA modification; tRNA-queuosine biosynthesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site81-82NADPH (UniProtKB | ChEBI)
Active site179Thioimide intermediate
Active site186Proton donor
Binding site218-219substrate
Binding site247-248NADPH (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionpreQ1 synthase activity
Biological Processqueuosine biosynthetic process
Biological ProcesstRNA modification

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADPH-dependent 7-cyano-7-deazaguanine reductase
  • EC number
  • Alternative names
    • 7-cyano-7-carbaguanine reductase
    • NADPH-dependent nitrile oxidoreductase
    • PreQ(0) reductase

Gene names

    • Name
      queF
    • ORF names
      A3H44_04375

Organism names

Accessions

  • Primary accession
    A0A1G0JJ69

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain12-121NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal

Sequence similarities

Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    273
  • Mass (Da)
    30,808
  • Last updated
    2017-02-15 v1
  • Checksum
    274FE3D4A4CDD388
MTDNPLGKHTLYPASYDPGLLFPIARLQNREKLGLAPQNVPFRGYDSWRAYELSWLDERGKPVVATGEFIVPSNSTFLTESKSLKLYLNSLNQMRFLNVDEVQQTISRDLSNATQSPVIVYLYTVDDERNLSISKPSGECLDQLDVAIDCYLPDPKFLSVEASVQVTETLYSNLFRSNCPVTSQPDWGTVVISYAGAAIDRAGLLRYLISFRAHEGFHEDCAERIFTDILRYAVPRSLSVSMNFLRRGGLEINPVRTNAPLDVDFPGPRYVRQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MGYS01000012
EMBL· GenBank· DDBJ
OGT74455.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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