A0A1G0JJ69 · A0A1G0JJ69_9GAMM
- ProteinNADPH-dependent 7-cyano-7-deazaguanine reductase
- GenequeF
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids273 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
Catalytic activity
- 7-aminomethyl-7-carbaguanine + 2 NADP+ = 7-cyano-7-deazaguanine + 3 H+ + 2 NADPH
Pathway
tRNA modification; tRNA-queuosine biosynthesis.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | preQ1 synthase activity | |
Biological Process | queuosine biosynthetic process | |
Biological Process | tRNA modification |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADPH-dependent 7-cyano-7-deazaguanine reductase
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria
Accessions
- Primary accessionA0A1G0JJ69
Proteomes
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 12-121 | NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal | ||||
Sequence: YPASYDPGLLFPIARLQNREKLGLAPQNVPFRGYDSWRAYELSWLDERGKPVVATGEFIVPSNSTFLTESKSLKLYLNSLNQMRFLNVDEVQQTISRDLSNATQSPVIVY |
Sequence similarities
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length273
- Mass (Da)30,808
- Last updated2017-02-15 v1
- Checksum274FE3D4A4CDD388