A0A1F9AM76 · A0A1F9AM76_9DELT

Function

function

Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis.

GO annotations

AspectTerm
Molecular Functionmetal ion binding
Molecular Functiontransferase activity
Biological Processthiamine biosynthetic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Thiamine pyrimidine synthase

Gene names

    • ORF names
      A2V65_04230

Organism names

Accessions

  • Primary accession
    A0A1F9AM76

Proteomes

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain47-257SsuA/THI5-like

Sequence similarities

Belongs to the NMT1/THI5 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    336
  • Mass (Da)
    37,970
  • Last updated
    2017-02-15 v1
  • Checksum
    51767CCEFC896050
MKKISIPIRFRPYGWAVLGALLLMMLPSAKLHAAERASYRLKWIFNASVLGDIYADVNGFFARQGLEVDVKAGGPERDAIMELELGRTEFGVASADQVIRALSKGARLKVIAQIFQVNPLQWMYRPDQMRIETLADLKGRRLGVTFGGNDESILRTLLTKGGLGENDVELFSVRNDFTPFLTKKVNFWPVYRNTQAVFLEAKLKDAGEPVEYFDPAAYGVKFVANSVITSMDIFENRPQLVRRFIKGLMEGWKAALDVNNRENALKTLQRYEKETPPDILKKQIELTRRLVQPDPGVPIGAIDTAAWRQTETIMSHQRQINAPVNIERVLVQIPPD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MGQD01000161
EMBL· GenBank· DDBJ
OGP58491.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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