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A0A1D8EJF9 · IF4E1_SOLPI

Function

function

Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity).
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (By similarity).
Key component of recessive resistance to potyviruses (PubMed:27655175).
(Microbial infection) Susceptibility host factor required for viral infection (e.g. potato virus Y (PVY) and tobacco etch virus (TEV)) by recruiting viral RNAs to the host ribosomal complex via an interaction with viral genome-linked protein (VPg).

Miscellaneous

Displayed sequence confers sensistivity to potyviruses (e.g. potato virus Y (PVY) and tobacco etch virus (TEV)).

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site74-79N7-methylguanosine 5'-triphosphate group (UniProtKB | ChEBI); m7GTP residue in mRNA cap of mRNA (UniProtKB | ChEBI)
Binding site106N7-methylguanosine 5'-triphosphate group (UniProtKB | ChEBI); m7GTP residue in mRNA cap of mRNA (UniProtKB | ChEBI)
Binding site124-125N7-methylguanosine 5'-triphosphate group (UniProtKB | ChEBI); m7GTP residue in mRNA cap of mRNA (UniProtKB | ChEBI)
Binding site174-179N7-methylguanosine 5'-triphosphate group (UniProtKB | ChEBI); m7GTP residue in mRNA cap of mRNA (UniProtKB | ChEBI)
Binding site219-223N7-methylguanosine 5'-triphosphate group (UniProtKB | ChEBI); m7GTP residue in mRNA cap of mRNA (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionRNA binding
Molecular Functiontranslation initiation factor activity
Biological Processdefense response to virus
Biological Processtranslational initiation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Eukaryotic translation initiation factor 4E-1
  • Short names
    eIF4E-1
  • Alternative names
    • eIF-4F 25 kDa subunit
    • eIF-4F p26 subunit
    • mRNA cap-binding protein

Gene names

    • Name
      eIF4E1

Organism names

  • Taxonomic identifier
  • Strains
    • cv. LA0409
    • cv. LA0411
    • cv. LA1245
    • cv. LA1420
    • cv. LA1478
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > asterids > lamiids > Solanales > Solanaceae > Solanoideae > Solaneae > Solanum > Solanum subgen. Lycopersicon

Accessions

  • Primary accession
    A0A1D8EJF9
  • Secondary accessions
    • A0A1D8EJG6
    • A0A1D8EJG7

Subcellular Location

Nucleus
Cytoplasm
Note: Binds to potyvirus viral genome-linked protein (VPg) in the nucleus and with potyvirus nuclear inclusion protein A (NIa-Pro) and nuclear inclusion protein B (NIb) in the cytoplasm.

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant54in strain: LA0411, LA1420 and LA0409, allele pot12, haplotypes 1 and 4
Natural variant58in strain: LA1478, LA1582 and LA1593, haplotype 2
Natural variant112in strain: LA0411, allele pot12, haplotype 4
Natural variant151in strain: LA1245, haplotype 3

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 4 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00004540621-231Eukaryotic translation initiation factor 4E-1
Disulfide bond129↔167

Post-translational modification

According to the redox status, the Cys-129-Cys-167 disulfide bridge may have a role in regulating protein function by affecting its ability to bind capped mRNA.

Keywords

Interaction

Subunit

EIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G. EIF4E is also known to interact with other partners. In higher plants two isoforms of EIF4F have been identified, named isoform EIF4F and isoform EIF(iso)4F. Isoform EIF4F has subunits p220 and p26, whereas isoform EIF(iso)4F has subunits p82 and p28.
(Microbial infection) Interacts with potyvirus viral genome-linked protein (VPg); this interaction is possible in susceptible hosts but impaired in resistant plants.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region56-59EIF4G-binding
Region66-102EIF4G-binding
Region150-159EIF4G-binding

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    231
  • Mass (Da)
    26,042
  • Last updated
    2022-02-23 v2
  • Checksum
    0DBFA3141790555C
MAAAEMERTMSFDAAEKLKAADGGGGEVDDELEEGEIVEESNDTASYLGKEITVKHPLEHSWTFWFDNPTTKSRQTAWGSSLRNVYTFSTVEDFWGAYNNIHHPSKLIMGADFHCFKHKIEPKWEDPVCANGGTWKMSFSKGKSDTSWLYTLLAMIGHQFDHGDEICGAVVSVRAKGEKIALWTKNAANETAQVSIGKQWKQFLDYSDSVGFIFHDDAKRLDRNAKNRYTV

Polymorphism

Variant present in the strains cv. LA0411, cv. LA1420 and cv. LA0409, allele pot12, haplotypes 1 and 4, is associated with an increased resistance to potato virus Y (PVY) isolates LYE90 and N605 but not to PVY isolate SON41g and to tobacco etch virus (TEV) isolates CAA10.

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KX855954
EMBL· GenBank· DDBJ
AOT21125.1
EMBL· GenBank· DDBJ
mRNA
KX855955
EMBL· GenBank· DDBJ
AOT21126.1
EMBL· GenBank· DDBJ
mRNA
KX855956
EMBL· GenBank· DDBJ
AOT21127.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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