A0A1C0V674 · A0A1C0V674_9CYAN

Function

function

Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; NAD+ biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionglycosyltransferase activity
Molecular Functionnicotinate phosphoribosyltransferase activity
Biological ProcessNAD salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Nicotinate phosphoribosyltransferase
  • EC number

Gene names

    • ORF names
      BCD67_03355

Organism names

Accessions

  • Primary accession
    A0A1C0V674

Proteomes

Subcellular Location

PTM/Processing

Post-translational modification

Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

Keywords

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain30-157Nicotinate phosphoribosyltransferase N-terminal
Domain178-294Nicotinate/nicotinamide phosphoribosyltransferase
Domain370-487Nicotinate phosphoribosyltransferase C-terminal
Region391-417Disordered

Sequence similarities

Belongs to the NAPRTase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    496
  • Mass (Da)
    54,594
  • Last updated
    2016-11-02 v1
  • Checksum
    758B5EA5D0265028
MKTVTESNAPIGLTVGEDQELTLSPEDYSLLTDLYQLTMVACYVGEGLDRQPASFELFTRKLPEDFGYLIAMGLAQALDYLEKFRFSPAQIEALQSTGIFANATEEFWKLLAETRFTGDIWAVPEGKAVFANEPLLRVDAPLWQAQLVETYLLNAINYQTLIATRSARLRDVAGPQAQLLEFGTRRAFSPQASIWAARAALAAGFDATSNVLAALKLGRKPAGTMAHALVMAVGATSGSEEAAFTAFHKYFPGAPLLIDTYDTITAARGLAELVNRGEIRLEGVRLDSGDLIELSREVRSLLPGIPIFASGDLDEWKISELKNAGACIDGYGLGTKLVSGFPINGVYKLVEINGVGVMKEANEKVTYPGRKQIFRYLQDGQVMGDCLGLMKEEGRGNEDEGRRNEDEGMRMKDEGRRNEDELSLVNCYQFPVPLMQLMVKDGKRVWPVESLEAIAQRTAVSVASLPAETRRLDNPLSPRVEISPELQILTQKTKKR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MBRE01000080
EMBL· GenBank· DDBJ
OCQ93295.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp