A0A1C0V674 · A0A1C0V674_9CYAN
- ProteinNicotinate phosphoribosyltransferase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids496 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
Catalytic activity
- nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate
Pathway
Cofactor biosynthesis; NAD+ biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | glycosyltransferase activity | |
Molecular Function | nicotinate phosphoribosyltransferase activity | |
Biological Process | NAD salvage |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNicotinate phosphoribosyltransferase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Cyanobacteriota > Cyanophyceae > Oscillatoriophycideae > Oscillatoriales
Accessions
- Primary accessionA0A1C0V674
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Post-translational modification
Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 30-157 | Nicotinate phosphoribosyltransferase N-terminal | ||||
Sequence: LLTDLYQLTMVACYVGEGLDRQPASFELFTRKLPEDFGYLIAMGLAQALDYLEKFRFSPAQIEALQSTGIFANATEEFWKLLAETRFTGDIWAVPEGKAVFANEPLLRVDAPLWQAQLVETYLLNAIN | ||||||
Domain | 178-294 | Nicotinate/nicotinamide phosphoribosyltransferase | ||||
Sequence: QLLEFGTRRAFSPQASIWAARAALAAGFDATSNVLAALKLGRKPAGTMAHALVMAVGATSGSEEAAFTAFHKYFPGAPLLIDTYDTITAARGLAELVNRGEIRLEGVRLDSGDLIEL | ||||||
Domain | 370-487 | Nicotinate phosphoribosyltransferase C-terminal | ||||
Sequence: RKQIFRYLQDGQVMGDCLGLMKEEGRGNEDEGRRNEDEGMRMKDEGRRNEDELSLVNCYQFPVPLMQLMVKDGKRVWPVESLEAIAQRTAVSVASLPAETRRLDNPLSPRVEISPELQ | ||||||
Region | 391-417 | Disordered | ||||
Sequence: KEEGRGNEDEGRRNEDEGMRMKDEGRR |
Sequence similarities
Belongs to the NAPRTase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length496
- Mass (Da)54,594
- Last updated2016-11-02 v1
- Checksum758B5EA5D0265028
Keywords
- Technical term