A0A1B8J8T2 · A0A1B8J8T2_9HELI

  • Protein
    Lipoprotein signal peptidase
  • Gene
    lspA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.
    EC:3.4.23.36 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; lipoprotein biosynthesis (signal peptide cleavage).

Features

Showing features for active site.

115320406080100120140
TypeIDPosition(s)Description
Active site109
Active site126

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionaspartic-type endopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lipoprotein signal peptidase
  • EC number
  • Alternative names
    • Prolipoprotein signal peptidase
    • Signal peptidase II
      (SPase II
      )

Gene names

    • Name
      lspA
    • ORF names
      BA723_05730
      , BKN38_06765

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • HMC1
    • CLO-3
  • Taxonomic lineage
    Bacteria > Campylobacterota > Epsilonproteobacteria > Campylobacterales > Helicobacteraceae > Helicobacter

Accessions

  • Primary accession
    A0A1B8J8T2

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane47-74Helical
Transmembrane81-99Helical
Transmembrane119-142Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the peptidase A8 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    153
  • Mass (Da)
    17,756
  • Last updated
    2016-11-02 v1
  • Checksum
    252F24E280FAB8AE
MRQKIFWLLLVIAVIALDQLIKSIILGGFRWHSEALSIVLVYNDGVAFSMLAFLQGYLKWLQIGFIALIVGYIFTQREIFARYWLGFGLMIGGGISNVIDRFVHGGVVDYVYWHYWFDFAIFNFADVMIDIGVACLIIAWLIHERRQRRAVCE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MAMQ01000064
EMBL· GenBank· DDBJ
OBV29350.1
EMBL· GenBank· DDBJ
Genomic DNA
MLQN01000022
EMBL· GenBank· DDBJ
OHU82608.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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