A0A1B7MPK1 · A0A1B7MPK1_9AGAM
- ProteinKetol-acid reductoisomerase, mitochondrial
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids406 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- (2R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (2S)-2-acetolactate + NADPH + H+
Cofactor
Note: Binds 2 magnesium ions per subunit.
Pathway
Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.
Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 264 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 264 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 268 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 300 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 304 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 326 | substrate | ||||
Sequence: S |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Molecular Function | isomerase activity | |
Molecular Function | ketol-acid reductoisomerase activity | |
Molecular Function | metal ion binding | |
Biological Process | isoleucine biosynthetic process | |
Biological Process | valine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameKetol-acid reductoisomerase, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Agaricomycetidae > Boletales > Suillineae > Rhizopogonaceae > Rhizopogon
Accessions
- Primary accessionA0A1B7MPK1
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-24 | Disordered | ||||
Sequence: MSDVAGRPLRAASRRAPRASTKIA | ||||||
Domain | 66-255 | KARI N-terminal Rossmann | ||||
Sequence: EEVVYERSDWPLAKLQDYFKNDTLALIGYGSQGHGQGLNARDNGLNVIVGVRKDGESWRQAMEDGWVPGETLFPIEEAINRGTIIMNLLSDAAQSQTWPTVAPLITKDKTLYFSHGFSVVYKEDTKVIPPKDVDVILVAPKGSGRTVRTLFKEGRGINSSVAVFQDVTGKAMEKAVALGVAVGSGYMYET | ||||||
Domain | 256-403 | KARI C-terminal knotted | ||||
Sequence: TFEKEVYSDLYGERGVLMGAIQGLFCAQYKVLRANGHTPSEAFNETVEEATQSLYPLIGQKGMDYMYNACSTTARRGALDWAPIFEKTNLPVFEQLYESVRNGTETRKSLEFNGRSTYRQDLAKELKEIDDQEIWRAGKVVRSLRPDY |
Sequence similarities
Belongs to the ketol-acid reductoisomerase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length406
- Mass (Da)44,794
- Last updated2016-11-02 v1
- Checksum9C4A07B07100CA4F
Keywords
- Technical term