A0A1B6EM82 · A0A1B6EM82_9HEMI
- ProteinBumetanide-sensitive sodium-(Potassium)-chloride cotransporter
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1039 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Catalytic activity
- K+(out) + 2 chloride(out) + Na+(out) = K+(in) + 2 chloride(in) + Na+(in)This reaction proceeds in the forward direction.K+ (out)CHEBI:29103
+ 2 chloride (out)CHEBI:17996+ Na+ (out)CHEBI:29101= K+ (in)CHEBI:29103+ 2 chloride (in)CHEBI:17996+ Na+ (in)CHEBI:29101
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell periphery | |
Cellular Component | membrane | |
Molecular Function | sodium:potassium:chloride symporter activity | |
Biological Process | cell volume homeostasis | |
Biological Process | chloride ion homeostasis | |
Biological Process | potassium ion homeostasis | |
Biological Process | potassium ion import across plasma membrane | |
Biological Process | sodium ion homeostasis |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameBumetanide-sensitive sodium-(Potassium)-chloride cotransporter
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Paraneoptera > Hemiptera > Auchenorrhyncha > Membracoidea > Cicadellidae > Cicadellinae > Proconiini > Cuerna
Accessions
- Primary accessionA0A1B6EM82
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 118-137 | Helical | ||||
Sequence: VLIPCLLNIWGVMLFLRLSW | ||||||
Transmembrane | 149-170 | Helical | ||||
Sequence: LIIAASAIVCVLTTLSMSAICT | ||||||
Transmembrane | 191-214 | Helical | ||||
Sequence: FGASVGVIFAFANAVAASMNTIGF | ||||||
Transmembrane | 239-258 | Helical | ||||
Sequence: IVGLIALLVMIIICAVGMEW | ||||||
Transmembrane | 265-283 | Helical | ||||
Sequence: FLVIIIILAIVDFLVGTLV | ||||||
Transmembrane | 321-343 | Helical | ||||
Sequence: LFTVFAIFFPSVTGIQAGANISG | ||||||
Transmembrane | 355-379 | Helical | ||||
Sequence: GTLLAVLISMTSYALFVIFAGGAAL | ||||||
Transmembrane | 420-442 | Helical | ||||
Sequence: AWGALIYAGCFAATLSTALTNLL | ||||||
Transmembrane | 477-497 | Helical | ||||
Sequence: YVLVFFISGAFILIAEINVIA | ||||||
Transmembrane | 503-524 | Helical | ||||
Sequence: FYLASYALINFCTFHAALVRPL | ||||||
Transmembrane | 536-569 | Helical | ||||
Sequence: WLSLVAFLTCIAIMFLINWLTSIITFIVFFVLYL |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 12-50 | Disordered | ||||
Sequence: QKGGGGIDNPAMDMGSIPTGLNLSPSALPDGSQDGLDRS | ||||||
Compositional bias | 30-50 | Polar residues | ||||
Sequence: TGLNLSPSALPDGSQDGLDRS | ||||||
Domain | 50-88 | Amino acid permease N-terminal | ||||
Sequence: SQSQSFCHLTMEALPRADYYKNNRDAIKRPSLGELHGEP | ||||||
Domain | 117-614 | Amino acid permease/ SLC12A | ||||
Sequence: GVLIPCLLNIWGVMLFLRLSWVVGQAGIMQSLLIIAASAIVCVLTTLSMSAICTNGEVKGGGIYYIISRSLGPEFGASVGVIFAFANAVAASMNTIGFCDSLNDLLKSHGLKIVDGGLTDVRIVGLIALLVMIIICAVGMEWESKAQNFLVIIIILAIVDFLVGTLVGPHDDLTKAKGFEGFSMDVFKENWGPAYRYSEGLNQDLFTVFAIFFPSVTGIQAGANISGDLKDPAGAIPKGTLLAVLISMTSYALFVIFAGGAALRDANGDVNFFYNGSVSNCTLVGGTCDYGLQNSYSVMQLMSAWGALIYAGCFAATLSTALTNLLSVPRLIQALGIDRIYPGLIFFSKGYGKHGEPYRGYVLVFFISGAFILIAEINVIAPLISNFYLASYALINFCTFHAALVRPLGWRPTFKYYNKWLSLVAFLTCIAIMFLINWLTSIITFIVFFVLYLVVMYRNPNVNWGSSTQAQTYKRALMTVHKLFNQSEHVKNYQPQVL | ||||||
Domain | 623-1039 | SLC12A transporter C-terminal | ||||
Sequence: RPPLVDLANLVTRNNSLLVCAEIWKQRLTYRQRVALTKQGQAWLAVRKVKGFFQITDGYKFEIAARGLIQCSGVGRLKPNVLMMGYKSDWLTCNTEDLQGYFNVLHDAFENRLAVTILRLAEGLDLAKPSDLTQYPEDVTGSLGDLSGNSNSGNGIVHNDSNLSYILPNVLSQTSLTIPGSKPPERPANPWQNSPSSALKEKKKKIASQILHKYEEGQEISKAVLDSMMTFSKKHKGGIIDVWWLYDDGGLTILLPYILSTRSSWADCKMRVFALANRTNELQSEEQGMASLLSKFRIKYTSLTMIHNISEPPKQETINFFENIISGFRESNKNAECTVSDMEYEALREKTYRQLRLRELLQQHSKQSNLVVMSLPMPRKGVVSAPLYMAWLEAITKDMPPFLLVRGNQTSVLTFYS | ||||||
Region | 798-820 | Disordered | ||||
Sequence: LTIPGSKPPERPANPWQNSPSSA |
Sequence similarities
Belongs to the SLC12A transporter family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,039
- Mass (Da)114,712
- Last updated2016-11-02 v1
- Checksum77649AC478B14EC0
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 30-50 | Polar residues | ||||
Sequence: TGLNLSPSALPDGSQDGLDRS |