A0A1B6EM82 · A0A1B6EM82_9HEMI

  • Protein
    Bumetanide-sensitive sodium-(Potassium)-chloride cotransporter
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Organism
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell periphery
Cellular Componentmembrane
Molecular Functionsodium:potassium:chloride symporter activity
Biological Processcell volume homeostasis
Biological Processchloride ion homeostasis
Biological Processpotassium ion homeostasis
Biological Processpotassium ion import across plasma membrane
Biological Processsodium ion homeostasis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Bumetanide-sensitive sodium-(Potassium)-chloride cotransporter

Gene names

    • ORF names
      g.30423
      , g.30424

Organism names

  • Taxonomic identifier
  • Organism
    Cuerna arida
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Paraneoptera > Hemiptera > Auchenorrhyncha > Membracoidea > Cicadellidae > Cicadellinae > Proconiini > Cuerna

Accessions

  • Primary accession
    A0A1B6EM82

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane118-137Helical
Transmembrane149-170Helical
Transmembrane191-214Helical
Transmembrane239-258Helical
Transmembrane265-283Helical
Transmembrane321-343Helical
Transmembrane355-379Helical
Transmembrane420-442Helical
Transmembrane477-497Helical
Transmembrane503-524Helical
Transmembrane536-569Helical

Keywords

  • Cellular component

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region12-50Disordered
Compositional bias30-50Polar residues
Domain50-88Amino acid permease N-terminal
Domain117-614Amino acid permease/ SLC12A
Domain623-1039SLC12A transporter C-terminal
Region798-820Disordered

Sequence similarities

Belongs to the SLC12A transporter family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,039
  • Mass (Da)
    114,712
  • Last updated
    2016-11-02 v1
  • Checksum
    77649AC478B14EC0
MAGRFNVAKAMQKGGGGIDNPAMDMGSIPTGLNLSPSALPDGSQDGLDRSQSQSFCHLTMEALPRADYYKNNRDAIKRPSLGELHGEPRTLDLHQEEKSGIPFDEEHKGMKLGWIQGVLIPCLLNIWGVMLFLRLSWVVGQAGIMQSLLIIAASAIVCVLTTLSMSAICTNGEVKGGGIYYIISRSLGPEFGASVGVIFAFANAVAASMNTIGFCDSLNDLLKSHGLKIVDGGLTDVRIVGLIALLVMIIICAVGMEWESKAQNFLVIIIILAIVDFLVGTLVGPHDDLTKAKGFEGFSMDVFKENWGPAYRYSEGLNQDLFTVFAIFFPSVTGIQAGANISGDLKDPAGAIPKGTLLAVLISMTSYALFVIFAGGAALRDANGDVNFFYNGSVSNCTLVGGTCDYGLQNSYSVMQLMSAWGALIYAGCFAATLSTALTNLLSVPRLIQALGIDRIYPGLIFFSKGYGKHGEPYRGYVLVFFISGAFILIAEINVIAPLISNFYLASYALINFCTFHAALVRPLGWRPTFKYYNKWLSLVAFLTCIAIMFLINWLTSIITFIVFFVLYLVVMYRNPNVNWGSSTQAQTYKRALMTVHKLFNQSEHVKNYQPQVLLLVGQPQSRPPLVDLANLVTRNNSLLVCAEIWKQRLTYRQRVALTKQGQAWLAVRKVKGFFQITDGYKFEIAARGLIQCSGVGRLKPNVLMMGYKSDWLTCNTEDLQGYFNVLHDAFENRLAVTILRLAEGLDLAKPSDLTQYPEDVTGSLGDLSGNSNSGNGIVHNDSNLSYILPNVLSQTSLTIPGSKPPERPANPWQNSPSSALKEKKKKIASQILHKYEEGQEISKAVLDSMMTFSKKHKGGIIDVWWLYDDGGLTILLPYILSTRSSWADCKMRVFALANRTNELQSEEQGMASLLSKFRIKYTSLTMIHNISEPPKQETINFFENIISGFRESNKNAECTVSDMEYEALREKTYRQLRLRELLQQHSKQSNLVVMSLPMPRKGVVSAPLYMAWLEAITKDMPPFLLVRGNQTSVLTFYS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias30-50Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GECZ01030739
EMBL· GenBank· DDBJ
JAS39030.1
EMBL· GenBank· DDBJ
Transcribed RNA
GECZ01015000
EMBL· GenBank· DDBJ
JAS54769.1
EMBL· GenBank· DDBJ
Transcribed RNA

Similar Proteins

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