A0A1B3B2W7 · A0A1B3B2W7_9SAUR

  • Protein
    Brain-derived neurotrophic factor
  • Gene
    bndf
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons as well as basal forebrain cholinergic neurons in the brain. Its relevance in the snake venom is not clear. However, it has been shown to inhibit metalloproteinase-dependent proteolysis of platelet glycoprotein Ib alpha, suggesting a metalloproteinase inhibition to prevent metalloprotease autodigestion and/or protection against prey proteases. Binds a lipid between the two protein chains in the homodimer. The lipid-bound form promotes histamine relase from mouse mast cells, contrary to the lipid-free form.
Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxon
Cellular Componentdendrite
Cellular Componentextracellular space
Cellular Componentsynaptic vesicle
Molecular Functiongrowth factor activity
Molecular Functionnerve growth factor receptor binding
Molecular Functiontoxin activity
Biological Processcell surface receptor protein tyrosine kinase signaling pathway
Biological Processmemory
Biological Processmodulation of chemical synaptic transmission
Biological Processnegative regulation of neuron apoptotic process
Biological Processnerve development
Biological Processnerve growth factor signaling pathway
Biological Processneuron projection morphogenesis
Biological Processperipheral nervous system development
Biological Processpositive regulation of collateral sprouting
Biological Processpositive regulation of peptidyl-serine phosphorylation
Biological Processregulation of neuron differentiation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Brain-derived neurotrophic factor
  • Short names
    BDNF

Gene names

    • Name
      bndf

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Lepidosauria > Squamata > Bifurcata > Unidentata > Episquamata > Toxicofera > Serpentes > Colubroidea > Elapidae > Acanthophiinae > Pseudonaja

Accessions

  • Primary accession
    A0A1B3B2W7

Subcellular Location

PTM/Processing

Keywords

Interaction

Subunit

Homodimer; non-covalently linked.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain119-221Nerve growth factor-related

Sequence similarities

Belongs to the NGF-beta family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    221
  • Mass (Da)
    24,889
  • Last updated
    2016-11-02 v1
  • Checksum
    310D34EA6B3729CF
SCMKAAPMKEVSIRGQGSLAYPGLRTKGNLETLSGPNDATRGLTSLADTFEHVIEELLDEQQVIQSSKENKDADLYSSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSTSEWVTAAEKKTAVDMSGATVTVLEKVPVPKGQLKQYFYETKCSTKGYAKEGCRGIDKRYWNSQCRTTQSYVRALTMDNKKRVGWRFIRIDT

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue221

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KX694752
EMBL· GenBank· DDBJ
AOE45618.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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