A0A182JEC6 · A0A182JEC6_ANOAO

Function

Catalytic activity

  • (5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP+ = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H+ + NADPH
    This reaction proceeds in the forward direction.
  • 13,14-dihydro-15-oxo-PGF2alpha + NADP+ = 15-oxoprostaglandin F2alpha + H+ + NADPH
    This reaction proceeds in the backward direction.
  • 13,14-dihydro-15-oxo-prostaglandin E1 + NADP+ = 15-oxoprostaglandin E1 + H+ + NADPH
    This reaction proceeds in the backward direction.
  • 13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP+ = 15-oxoprostaglandin F1alpha + H+ + NADPH
    This reaction proceeds in the backward direction.
  • 20-hydroxy-leukotriene B4 + NADP+ = 12-oxo-20-hydroxy-leukotriene B4 + H+ + NADPH
    This reaction proceeds in the forward direction.
  • 4-hydroxynonanal + NADP+ = (E)-4-hydroxynon-2-enal + H+ + NADPH
    This reaction proceeds in the backward direction.
  • 6-trans-leukotriene B4 + NADP+ = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H+ + NADPH
    This reaction proceeds in the forward direction.
  • NADP+ + nonan-2-one = (3E)-nonen-2-one + H+ + NADPH
    This reaction proceeds in the backward direction.
  • NADP+ + octanal = (2E)-octenal + H+ + NADPH
    This reaction proceeds in the backward direction.
  • NADP+ + pentan-2-one = (E)-pent-3-en-2-one + H+ + NADPH
    This reaction proceeds in the backward direction.
  • an n-alkanal + NADP+ = an alk-2-enal + H+ + NADPH
    This reaction proceeds in the backward direction.
    EC:1.3.1.74 (UniProtKB | ENZYME | Rhea)
  • decanal + NADP+ = (2E)-decenal + H+ + NADPH
    This reaction proceeds in the backward direction.
  • dodecanal + NADP+ = (2E)-dodecenal + H+ + NADPH
    This reaction proceeds in the backward direction.
  • hexanal + NADP+ = (E)-hex-2-enal + H+ + NADPH
    This reaction proceeds in the backward direction.
  • leukotriene B4 + NADP+ = 12-oxo-leukotriene B4 + H+ + NADPH
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function13-prostaglandin reductase activity
Molecular Function15-oxoprostaglandin 13-oxidase activity
Molecular Function2-alkenal reductase [NAD(P)+] activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Prostaglandin reductase 1
  • EC number
  • Alternative names
    • 15-oxoprostaglandin 13-reductase
    • Dithiolethione-inducible gene 1 protein
    • Leukotriene B4 12-hydroxydehydrogenase
    • NAD(P)H-dependent alkenal/one oxidoreductase

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Anophelinae > Anopheles

Accessions

  • Primary accession
    A0A182JEC6

Organism-specific databases

Subcellular Location

PTM/Processing

Keywords

Interaction

Subunit

Monomer or homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the NADP-dependent oxidoreductase L4BD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    662
  • Mass (Da)
    72,528
  • Last updated
    2016-09-07 v1
  • Checksum
    C45DE1A9CE6A7B9C
MYIAKKWIYAKPFVGEPTQDNFQLVEEAVPELADGEFMIRAMFLSVDPYMRIYVLSSPIGSTMIGGQVGQVIESKNSAFPVGSYAFAQVGWRTISVCDPAKFETRKPYVLPDLHGLPLSLGAGALGTVGNTAYFGLLEICNPQPGETVVVSGAAGAVGSMVGQIAKIKGCRVIGIAGTDAKCCWLKEIGFDETINYKTDNIETALAGAAPDGVDCYFDNVGGQTSAIVKGQMKKFGRISVCGTISMYNGQPAKVVDPQLDFVWKQLIQEGFSVHRWTDRWFEGVTQNLQWIRDGKLKCRETITEGFENMPSAFIDMLKEAISLSICARRYYSSGDVARKWIYAKTFRGEPTHANFRQETEPIPSLQDGEFLAEAEYLSVDPYMRPYMLAYPEGTLMIGGQVARVTKSAHPRFPVGATIFGQFGWRTHTVCNPDRLEKDKPYVLPNFGGLPKSLGLGLLGMPGNTAYFGLQELCQPKPGETVVVSGAAGAVGSAVGQLAKHLGCRAVGVAGSDAKCEWLLKLGFDSAINYKHSNVYADLKKAAPKGIDCYFDNVGGEISEAVIKQMNVCGRIAVCGAISNYNTTVAKVTDPQRQFVFKQLRMEGFLVWRWNDRWMEGIEANLRLIHEGKLRYEETVTEGFDKMPDAFIDMLRGGNTGKAVVKV

Genome annotation databases

Similar Proteins

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