A0A182F1I0 · A0A182F1I0_ANOAL

Function

function

Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine34 acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

Pathway

tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site101[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site111[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site114[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentelongator holoenzyme complex
Cellular Componentnucleus
Molecular Functionacyltransferase activity, transferring groups other than amino-acyl groups
Molecular Functioniron-sulfur cluster binding
Molecular Functionmetal ion binding
Molecular FunctiontRNA binding
Biological ProcesstRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Elongator complex protein 3
  • EC number

Organism names

  • Taxonomic identifier
  • Strain
    • ALBI9_A
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Anophelinae > Anopheles

Accessions

  • Primary accession
    A0A182F1I0

Proteomes

Organism-specific databases

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the ELP3 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    549
  • Mass (Da)
    62,435
  • Last updated
    2016-09-07 v1
  • Checksum
    EDFDB44DE31272F4
MTKKKPLGIGLSRDERMLIVVGEIIQELLKAHREGKDVNLNRLKTRISSNYGLESAPRLVDIIAAVPHEAKSILLPKLRAKPIRTASGIAVVAVMCKPHRCPHINMTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYHPFLQTRHRVEQLKQLGHSVDKVEFIVMGGTFMCLPEDYRDFFIRNLHDALSGHTSSSVAEAVKYSERSHTKCIGITIETRPDYCLKRHLSDLLAYGCTRLEIGVQSVYEDVARDTNRGHTVKATCESFQMSKDAGFKVVSHMMPDLPNVDIERDIEQFIEFFENPDFRADGLKIYPTLVIRGTGLYELWKTGRYKSYPPSTLVDLVAKILALVPPWTRVYRVQRDIPMPLVTSGVEHGNLRELALARMKDLGTDCRDVRTREVGIQEIHNKVRPYEIELIRRDYVANGGWETFLSYEDPKQDILVGLLRLRKCSPDTFRPELLNGCSIVRELHVYGSVVPVNARDPTKFQHQGFGMLLMEEAERIARDEHGSRKLAVISGVGTRNYYRKMGYELDGPYMSKMLI

Genome annotation databases

Similar Proteins

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