A0A158K4Q0 · A0A158K4Q0_9BURK

  • Protein
    6-phosphogluconate dehydrogenase, decarboxylating
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.

Catalytic activity

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.

Features

Showing features for binding site, active site.

146850100150200250300350400450
TypeIDPosition(s)Description
Binding site10-15NADP+ (UniProtKB | ChEBI)
Binding site33-35NADP+ (UniProtKB | ChEBI)
Binding site74-76NADP+ (UniProtKB | ChEBI)
Binding site102NADP+ (UniProtKB | ChEBI)
Binding site102substrate; ligand shared between dimeric partners; in other chain
Binding site128-130substrate; ligand shared between dimeric partners; in other chain
Active site183Proton acceptor
Binding site186-187substrate; ligand shared between dimeric partners; in other chain
Active site190Proton donor
Binding site191substrate; ligand shared between dimeric partners; in other chain
Binding site261substrate; ligand shared between dimeric partners; in other chain
Binding site288substrate; ligand shared between dimeric partners; in other chain
Binding site446substrate; ligand shared between dimeric partners
Binding site452substrate; ligand shared between dimeric partners

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionNADP binding
Molecular Functionphosphogluconate dehydrogenase (decarboxylating) activity
Biological ProcessD-gluconate catabolic process
Biological Processpentose-phosphate shunt, oxidative branch

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    6-phosphogluconate dehydrogenase, decarboxylating
  • EC number

Gene names

    • ORF names
      AWB67_04869

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • LMG 22937
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Caballeronia

Accessions

  • Primary accession
    A0A158K4Q0

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain179-4686-phosphogluconate dehydrogenase C-terminal

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    468
  • Mass (Da)
    51,289
  • Last updated
    2017-09-27 v1
  • Checksum
    2557CD146069C7FF
MSKQAIGVVGLAVMGRNLALNIESRGHAVSVYNRSREKTDELIAEHPDKKLVPAFTLEEFVESLETPRRILLMVKAGVGTDATIDALRPLLQKGDILIDGGNTHFTDTIRRNQDLAKSGLHFIGTGVSGGEEGALKGPSIMPGGQREAYDLVAPILTEIAAKAPDGEPCVAYMGPDGAGHFVKMVHNGIEYGDMQLIAESYDVLKRVAGLSNEELHEVYSEWNKGELDSYLIEITTKIFTKKDEETGQHLVDVILDRAAQKGTGKWTSQNALDLGAPLPLITEAVFARVLSSLKDQRVKASKQLSGPSPKFDGDRAAFIESVRRALYLSKIVSYAQGFAQLRAASDEYKWDLHYGEIAKIFRAGCIIRARFLQKITDAYAKDEALANLLLDPYFSDIAAKYQDALRDVVVAAVKAGVPVPAFSSAVAYFDSYRSERLPANLVQAQRDFFGAHTFERVDKKGSFHADWA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FCOL02000036
EMBL· GenBank· DDBJ
SAL76102.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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