A0A143PFJ1 · A0A143PFJ1_LUTPR

  • Protein
    3-isopropylmalate dehydratase large subunit
  • Gene
    leuC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site346[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site406[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site409[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function3-isopropylmalate dehydratase activity
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionmetal ion binding
Biological ProcessL-leucine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-isopropylmalate dehydratase large subunit
  • EC number
  • Alternative names
    • Alpha-IPM isomerase
      (IPMI
      )
    • Isopropylmalate isomerase

Gene names

    • Name
      leuC
    • ORF names
      LuPra_00018

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • DSM 100886 HEG_-6_39
  • Taxonomic lineage
    Bacteria > Acidobacteriota > Vicinamibacteria > Vicinamibacterales > Vicinamibacteraceae > Luteitalea

Accessions

  • Primary accession
    A0A143PFJ1

Proteomes

Interaction

Subunit

Heterodimer of LeuC and LeuD.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-457Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha

Sequence similarities

Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    479
  • Mass (Da)
    51,596
  • Last updated
    2016-06-08 v1
  • Checksum
    4E8056D980446B53
MGHTLIQKVWDQHTVRTLPTGQTQLFIGLHLVHEVTTPQAFDDLRRRGWPVRFPERTFATVDHIVPTGSLARPFQDTMAEAMLSALERNCRDFGVPLYDHSTGRQGIVHVIGPELGLTQPGMTIACGDSHTSTHGAFGAVAFGIGTSQVRDVLASQCLAMEPLKVRRIRVQGVLQRGVYAKDVILKIIQVLGVKGGVGYAYEYAGSAVDGMSMDERMTMCNMSIEGGARVGYVNPDETTFAYMEGRPFAPQGEAFERAKGWWRSIASDADASYDDDVELRADSLGPVVTWGLHPGQSVGVDERVPTPGEVPAEDRPLVEEALQFMGFAPGQAIEGTPIDVAFVGSCTNSRLSDLREAARFVRGQKVARSVRAMVVPGSQAIRAQAEAEGLHEIFMAAGFDWRGSGCSMCLGMNPDKLLGREISASSSNRNFKGRQGSPTGRTLLMSPAMVAAAAIAGQVVDIRKFEPAAVEPPLVGGRA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP015136
EMBL· GenBank· DDBJ
AMY06858.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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