A0A0V1J984 · A0A0V1J984_TRIPS

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • (5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP+ = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H+
    This reaction proceeds in the forward direction.
  • 13,14-dihydro-15-oxo-PGF2alpha + NADP+ = 15-oxoprostaglandin F2alpha + NADPH + H+
    This reaction proceeds in the backward direction.
  • 13,14-dihydro-15-oxo-prostaglandin E1 + NADP+ = 15-oxoprostaglandin E1 + NADPH + H+
    This reaction proceeds in the backward direction.
  • 13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP+ = 15-oxoprostaglandin F1alpha + NADPH + H+
    This reaction proceeds in the backward direction.
  • 20-hydroxy-leukotriene B4 + NADP+ = 12-oxo-20-hydroxy-leukotriene B4 + NADPH + H+
    This reaction proceeds in the forward direction.
  • 4-hydroxynonanal + NADP+ = (E)-4-hydroxynon-2-enal + NADPH + H+
    This reaction proceeds in the backward direction.
  • 6-trans-leukotriene B4 + NADP+ = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H+
    This reaction proceeds in the forward direction.
  • nonan-2-one + NADP+ = (3E)-nonen-2-one + NADPH + H+
    This reaction proceeds in the backward direction.
  • octanal + NADP+ = (2E)-octenal + NADPH + H+
    This reaction proceeds in the backward direction.
  • pentan-2-one + NADP+ = (E)-pent-3-en-2-one + NADPH + H+
    This reaction proceeds in the backward direction.
  • an n-alkanal + NADP+ = an alk-2-enal + NADPH + H+
    This reaction proceeds in the backward direction.
    EC:1.3.1.74 (UniProtKB | ENZYME | Rhea)
  • decanal + NADP+ = (2E)-decenal + NADPH + H+
    This reaction proceeds in the backward direction.
  • dodecanal + NADP+ = (2E)-dodecenal + NADPH + H+
    This reaction proceeds in the backward direction.
  • hexanal + NADP+ = (E)-hex-2-enal + NADPH + H+
    This reaction proceeds in the backward direction.
  • leukotriene B4 + NADP+ = 12-oxo-leukotriene B4 + NADPH + H+
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function15-oxoprostaglandin 13-oxidase [NAD(P)+] activity
Molecular Function2-alkenal reductase [NAD(P)+] activity
Biological Processprostaglandin metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Prostaglandin reductase 1
  • EC number
  • Alternative names
    • 15-oxoprostaglandin 13-reductase
    • Dithiolethione-inducible gene 1 protein
    • Leukotriene B4 12-hydroxydehydrogenase
    • NAD(P)H-dependent alkenal/one oxidoreductase

Gene names

    • Name
      Ptgr1
    • ORF names
      T4B_990

Organism names

Accessions

  • Primary accession
    A0A0V1J984

Proteomes

Subcellular Location

PTM/Processing

Keywords

Interaction

Subunit

Monomer or homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain15-110Oxidoreductase N-terminal
Domain164-257Alcohol dehydrogenase-like C-terminal

Sequence similarities

Belongs to the NADP-dependent oxidoreductase L4BD family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    397
  • Mass (Da)
    44,381
  • Last updated
    2016-03-16 v1
  • Checksum
    8A36711F16235F15
MTKKEQTPKTVTAQRWIVMKPFDGYPKLSDFAISLTPLRKLQTGEFRCKGLLWSVEPFTRVMDVDLNSKPLVQSLQVAEVVESRNPAFSVGSVVIGYFGWCTDCITNGQEALCKAYHIGDLHSLPLSASVGAFGLSGIAAYVGFVERCNPQLGSIVVVNAAAGGVGHLVCQMAMFYRCVLIAFVGSDEKVNWLKTFIDAKFVYNYKTVDVGKLLDEIVPDGVDIFFDSVGGEFANKVMVRMKKGGRMCLCGTISDYNDTKSKKDSCVRADYGLAKRRGFIIRPLSALALRSRWPDLIPKVMELFCKGAMRYREQRYMGFENLPQALIDQLNGDTFGRVAVYASLHAFVFYYLITVWRNHILPQTSVPCHLVLKKIKWGVEAKNCECFLQCFKVDQIG

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue397

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JYDS01000024
EMBL· GenBank· DDBJ
KRZ31513.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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