A0A0U1ZJ07 · A0A0U1ZJ07_TRITC
- ProteinNADH-ubiquinone oxidoreductase chain 5
- GeneND5
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids612 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Catalytic activity
- a ubiquinone + NADH + 5 H+(in) = a ubiquinol + NAD+ + 4 H+(out)
a ubiquinone RHEA-COMP:9565 + CHEBI:57945 + 5 H+ (in)CHEBI:15378= a ubiquinol RHEA-COMP:9566 + CHEBI:57540 + 4 H+ (out)CHEBI:15378
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Molecular Function | NADH dehydrogenase activity | |
Biological Process | ATP synthesis coupled electron transport | |
Biological Process | electron transport coupled proton transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 5
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Anabantaria > Anabantiformes > Anabantoidei > Osphronemidae > Luciocephalinae > Trichopodus
Accessions
- Primary accessionA0A0U1ZJ07
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-28 | Helical | ||||
Sequence: IILTSTLILTLAILSHPLILTLT | ||||||
Transmembrane | 49-69 | Helical | ||||
Sequence: FFISLLPLALFLSEGAETITT | ||||||
Transmembrane | 89-110 | Helical | ||||
Sequence: FYSLIFLPIAFYVTWSILEFAS | ||||||
Transmembrane | 122-139 | Helical | ||||
Sequence: FFKYLLVFLIAMIILVTA | ||||||
Transmembrane | 145-165 | Helical | ||||
Sequence: LFIGWEGVGIMSFLLIGWWYG | ||||||
Transmembrane | 177-195 | Helical | ||||
Sequence: VIYNRVGDIGLIFSMAWFA | ||||||
Transmembrane | 215-235 | Helical | ||||
Sequence: LTPALIGLIIAATGKSAQFGL | ||||||
Transmembrane | 247-267 | Helical | ||||
Sequence: TPVSALLHSSTMVVAGIFLLV | ||||||
Transmembrane | 279-300 | Helical | ||||
Sequence: ALTTCLCLGALTTFFTATCALT | ||||||
Transmembrane | 307-325 | Helical | ||||
Sequence: IVAFSTSSQLGLMMVAIGL | ||||||
Transmembrane | 331-353 | Helical | ||||
Sequence: AFLHICTHAFFKAMLFLCSGSII | ||||||
Transmembrane | 374-393 | Helical | ||||
Sequence: FTSSCFTLGSLALTGTPFLA | ||||||
Transmembrane | 413-439 | Helical | ||||
Sequence: WALVLTILATSFTAVYSLRLIFFVAMG | ||||||
Transmembrane | 460-478 | Helical | ||||
Sequence: LKRLAWGSIVAGLLITSYT | ||||||
Transmembrane | 490-511 | Helical | ||||
Sequence: LLIKLAALIVTIAGLLIALDLA | ||||||
Transmembrane | 594-611 | Helical | ||||
Sequence: AYITLFFFTLILAILLVS |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 73-123 | NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal | ||||
Sequence: WMNTLTFDINVSFKFDFYSLIFLPIAFYVTWSILEFASWYMHSDPYMNRFF | ||||||
Domain | 139-421 | NADH:quinone oxidoreductase/Mrp antiporter membrane subunit | ||||
Sequence: ANNMFQLFIGWEGVGIMSFLLIGWWYGRADANTAALQAVIYNRVGDIGLIFSMAWFATNLNSWEMQQMFSTSQDMNLTPALIGLIIAATGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLVRMSPLMENNPTALTTCLCLGALTTFFTATCALTQNDIKKIVAFSTSSQLGLMMVAIGLNQPQLAFLHICTHAFFKAMLFLCSGSIIHSLNDEQDIRKMGGMHHLTPFTSSCFTLGSLALTGTPFLAGFFSKDAIIEALNTSYLNAWALVLTILA | ||||||
Domain | 428-609 | NADH dehydrogenase subunit 5 C-terminal | ||||
Sequence: YSLRLIFFVAMGHPRFAPLSPINENNPTVINPLKRLAWGSIVAGLLITSYTTPFKTPILTMPLLIKLAALIVTIAGLLIALDLASLTNKQFKPTPSLHLHHFSNMLGFFPAIIHRLAPKLNLTLGQTIASQMVDQTWLEKTGPKAVYTLNLPMITTTSNIQQGMIKAYITLFFFTLILAILL |
Sequence similarities
Belongs to the complex I subunit 5 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length612
- Mass (Da)67,570
- Last updated2016-03-16 v1
- Checksum0898830A51A4B108
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KP100265 EMBL· GenBank· DDBJ | AJW75156.1 EMBL· GenBank· DDBJ | Genomic DNA |