A0A0R2D1G0 · A0A0R2D1G0_9LACO

Function

function

Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • ATP + H2O + a folded polypeptide = ADP + phosphate + an unfolded polypeptide.
    EC:5.6.1.7 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site.

153950100150200250300350400450500
TypeIDPosition(s)Description
Binding site29-32ATP (UniProtKB | ChEBI)
Binding site86-90ATP (UniProtKB | ChEBI)
Binding site413ATP (UniProtKB | ChEBI)
Binding site476-478ATP (UniProtKB | ChEBI)
Binding site492ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular ComponentGroEL-GroES complex
Molecular FunctionATP binding
Molecular FunctionATP-dependent protein folding chaperone
Molecular Functionisomerase activity
Molecular Functionunfolded protein binding
Biological Processchaperone cofactor-dependent protein refolding
Biological Processprotein refolding
Biological Processresponse to heat

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Chaperonin GroEL
  • EC number
  • Alternative names
    • 60 kDa chaperonin
    • Chaperonin-60
      (Cpn60
      )

Gene names

    • Name
      groEL
    • Synonyms
      groL
    • ORF names
      FC56_GL000155

Organism names

Accessions

  • Primary accession
    A0A0R2D1G0

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the chaperonin (HSP60) family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    539
  • Mass (Da)
    56,975
  • Last updated
    2016-01-20 v1
  • Checksum
    57DE2A1E2F1B85C7
MAKEIKFSEDARTSMLKGVDKLANTVKTTIGPKGRNVVLEQTAGNPTITNDGVTIAKAIDLPDHFENMGAKLVSEVASKTNDVAGDGTTTATVLTQAIVNEGMKNVTAGANPVGIRRGIEQATKTAVAALHNMSHDVKTKEDIAQIASISSANEEVGKLIADAMEKVGNDGVITIEESRGVDTSLDVVEGMQFDRGYMSQYMVTDNDKMEADLDNPYILVTDKKINNIQDVLPLLQQIVEQGRSLLIIADDIGGEALPTLVLNKMRGTFNVVAVKAPGFGDRRKDQLQDIAILTGATVITDDLGLNLKDTTIDQLGQAGKVNVTKDATMIVEGAGSKDAIAARVEEIKGQIETTTSDFDRDKLKERLAKLSGGVAVVRVGAATETELKEKKYRIEDALNATRAAVEEGFVPGGGTALINVIPDVAKLEAEGDEATGIKIVQRALEEPVRQIAENAGVEGSVIVEKLKNEKPGIGYNAANGEFEDMIADGIVDPTKVTRSALQNAASVSALLLTTEAVVAEEPKDDSAPMAPAMPGGMGM

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AYZR01000008
EMBL· GenBank· DDBJ
KRM93443.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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