A0A0Q8C7Q8 · A0A0Q8C7Q8_9PSED

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Ni cation (UniProtKB | Rhea| CHEBI:25516 )

Note: Binds 2 nickel ions per subunit.

Pathway

Nitrogen metabolism; urea degradation; CO2 and NH3 from urea (urease route): step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site133Ni2+ 1 (UniProtKB | ChEBI)
Binding site135Ni2+ 1 (UniProtKB | ChEBI)
Binding site216Ni2+ 1 (UniProtKB | ChEBI); via carbamate group
Binding site216Ni2+ 2 (UniProtKB | ChEBI); via carbamate group
Binding site218substrate
Binding site245Ni2+ 2 (UniProtKB | ChEBI)
Binding site271Ni2+ 2 (UniProtKB | ChEBI)
Active site319Proton donor
Binding site359Ni2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionnickel cation binding
Molecular Functionurease activity
Biological Processurea catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Urease subunit alpha
  • EC number
  • Alternative names
    • Urea amidohydrolase subunit alpha

Gene names

    • Name
      ureC
    • ORF names
      ASD70_07655

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Root569
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A0Q8C7Q8

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue216N6-carboxylysine

Post-translational modification

Carbamylation allows a single lysine to coordinate two nickel ions.
Carboxylation allows a single lysine to coordinate two nickel ions.

Interaction

Subunit

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain128-566Urease

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    566
  • Mass (Da)
    60,667
  • Last updated
    2016-01-20 v1
  • Checksum
    4C5543447B002308
MKISRQAYADMYGPTVGDKVRLADTDLFIEVEQDFTVYGEEVKFGGGKVIRDGQGQSQLLAHEVVDTLITNALIIDHWGIVKADVGLKNGRIHAIGKAGNPDIQPGVTMAIGASTEVIAGEGMILTAGGIDSHVHFICPQQIEEALTSGVTTMIGGGTGPATGTNATTCTSGPWHLARMLQASDSFPMNIGFTGKGNASLPEPLIEQVKAGAIGLKLHEDWGTTPASIDNCLSVADQYDVQVAIHSDTLNESGFVETTLAALKGRTIHTYHTEGAGGGHAPDIIKACGYPNVLPSSTNPTRPFTRNTIDEHLDMLMVCHHLDPSIAEDVAFAESRIRRETIAAEDILHDLGAFSMISSDSQAMGRVGEVITRTWQTADKMKKQRGALPGDGPGNDNFRAKRYIAKYTINPAITHGISHIVGSIEVGKWADLVLWRPAFFGIKPTLILKGGAIASSLMGDANASIPTPQPVHYRPMFASFGSALHATSLTFISQAAQDAGLPEALGLKKQIAVVKGCRDVQKTDLIHNDYLPEIEVDPQTYQVKADGQLLWCEPADVLPMAQRYFLF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LMGQ01000024
EMBL· GenBank· DDBJ
KRA10160.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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