A0A0Q6B8Z2 · A0A0Q6B8Z2_9HYPH

  • Protein
    4-hydroxy-tetrahydrodipicolinate reductase
  • Gene
    dapB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site10-15NAD+ (UniProtKB | ChEBI)
Binding site36NAD+ (UniProtKB | ChEBI)
Binding site37NADP+ (UniProtKB | ChEBI)
Binding site98-100NAD+ (UniProtKB | ChEBI)
Binding site123-126NAD+ (UniProtKB | ChEBI)
Active site157Proton donor/acceptor
Binding site158(S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI)
Active site161Proton donor
Binding site167-168(S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function4-hydroxy-tetrahydrodipicolinate reductase
Molecular FunctionNAD binding
Molecular FunctionNADP binding
Molecular Functionoxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
Biological Processdiaminopimelate biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxy-tetrahydrodipicolinate reductase
  • EC number
  • Short names
    HTPA reductase

Gene names

    • Name
      dapB
    • ORF names
      ASG43_17175

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Leaf454
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Aurantimonadaceae > Aureimonas

Accessions

  • Primary accession
    A0A0Q6B8Z2

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-126Dihydrodipicolinate reductase N-terminal
Domain129-266Dihydrodipicolinate reductase C-terminal

Sequence similarities

Belongs to the DapB family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    269
  • Mass (Da)
    27,062
  • Last updated
    2016-01-20 v1
  • Checksum
    EF017551B968C416
MDEMRLVVMGASGRMGRALIAAIEETTGLVLHAAVERPGSPAVGATVGATVGSGAIEITDRLDHALDGADGVVDFTAPASSVAVAALAARLGLVHVIGTTGCSAADDEAIAAAAAAGARIVKSGNMSLGVNLVAGLVKLAARSLPADAFDIEILEMHHRHKVDAPSGTALLLGTAAAEGRGVPLAEASVRVRDGHTGARPQGAIGFATLRGGSVVGDHQVILAGEGERIELSHRADDRSIFARGALRAALWARSQAPGLYSMQDVLGLG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LMQT01000025
EMBL· GenBank· DDBJ
KQT42012.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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